RPD3/YNL330C Protein Information 
| Standard Name | Rpd3p 1 |
|---|---|
| Systematic Name | Ynl330cp |
| Alias | Rec3p 2 , Sdi2p 3 , Sds6p 4, 5 , Mof6p 6 |
| ORF Classification | Verified |
| Description | Histone deacetylase; regulates transcription, silencing, autophagy and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members; Rpd3(L) recruitment to the subtelomeric region is regulated by interaction with the arginine methyltransferase, Hmt1p (10, 11, 12, 13, 14, 15, 7, 8, 9) |
| Name Description | Reduced Potassium Dependency 1 |
| Experimental Data | |
|---|---|
| Molecules/cell | 3850 16 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Rpd3p (InterPro) |
| Physical Interactions | There are 204 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000053137 | P32561 MIPS: YNL330C NCBI: 1302451 | 2253190 | 238962 | 417699 | 51013077 | 6323999 | 642338 | 854536 | NP_014069.1 GenBank/EMBL/DDBJ: DAA10233.1 | AY692813 | S66438 | X83226 | Z46259 | Z71605 | Z71606 |
external links for Rpd3p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Aspergillus (AspGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CGD) | CYC2008 (complexes) | Pfam domains | |
| Candida (CandidaDB) | Complexome | YeastRC Structure Prediction (Seattle) | |
| YGOB | DIP | ||
| YOGY | GeneMANIA |
References cited on this page View Complete Literature Guide for Rpd3p
| 1) | Vidal M, et al. (1990) Direct selection for mutants with increased K+ transport in Saccharomyces cerevisiae. Genetics 125(2):313-20 |
| 2) | Dora EG, et al. (1999) RPD3 (REC3) mutations affect mitotic recombination in Saccharomyces cerevisiae. Curr Genet 35(2):68-76 |
| 3) | Stillman DJ, et al. (1994) Epistasis analysis of suppressor mutations that allow HO expression in the absence of the yeast SW15 transcriptional activator. Genetics 136(3):781-8 |
| 4) | Sussel L, et al. (1993) Epigenetic switching of transcriptional states: cis- and trans-acting factors affecting establishment of silencing at the HMR locus in Saccharomyces cerevisiae. Mol Cell Biol 13(7):3919-28 |
| 5) | Sussel L, et al. (1995) Suppressors of defective silencing in yeast: effects on transcriptional repression at the HMR locus, cell growth and telomere structure. Genetics 141(3):873-88 |
| 6) | Meskauskas A, et al. (2003) Delayed rRNA processing results in significant ribosome biogenesis and functional defects. Mol Cell Biol 23(5):1602-13 |
| 7) | Rundlett SE, et al. (1996) HDA1 and RPD3 are members of distinct yeast histone deacetylase complexes that regulate silencing and transcription. Proc Natl Acad Sci U S A 93(25):14503-8 |
| 8) | Carrozza MJ, et al. (2005) Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription. Cell 123(4):581-92 |
| 9) | Nyswaner KM, et al. (2008) Chromatin-associated genes protect the yeast genome from ty1 insertional mutagenesis. Genetics 178(1):197-214 |
| 10) | Zhou J, et al. (2009) Histone deacetylase Rpd3 antagonizes Sir2-dependent silent chromatin propagation. Nucleic Acids Res 37(11):3699-713 |
| 11) | Knott SR, et al. (2009) Genome-wide replication profiles indicate an expansive role for Rpd3L in regulating replication initiation timing or efficiency, and reveal genomic loci of Rpd3 function in Saccharomyces cerevisiae. Genes Dev 23(9):1077-90 |
| 12) | Kremer SB and Gross DS (2009) SAGA and Rpd3 Chromatin Modification Complexes Dynamically Regulate Heat Shock Gene Structure and Expression. J Biol Chem 284(47):32914-31 |
| 13) | Ruiz-Roig C, et al. (2010) The Rpd3L HDAC complex is essential for the heat stress response in yeast. Mol Microbiol 76(4):1049-62 |
| 14) | Yi C, et al. (2012) Function and molecular mechanism of acetylation in autophagy regulation. Science 336(6080):474-7 |
| 15) | Milliman EJ, et al. (2012) Recruitment of rpd3 to the telomere depends on the protein arginine methyltransferase hmt1. PLoS One 7(8):e44656 |
| 16) | Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41 |
