ZIM17/YNL310C Protein Information

Standard Name	Zim17p 1
Systematic Name	Ynl310cp
Alias	Tim15p 2 , Hep1p 3
ORF Classification	Verified
Description	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix (1, 3, 4)
Name Description	ZInc finger Motif protein of 17 kDa 1

Experimental Data
Molecules/cell	1520 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	174
Molecular Weight (Da)	19,855
Isoelectric Point (pI)	10.15

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Zim17p (InterPro)
Physical Interactions	There are 11 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000D796A4 \| P42844 MIPS: YNL310C NCBI: 1176588 \| 1302413 \| 159164308 \| 166897668 \| 45270622 \| 633672 \| 99030930 \| NP_014089.2 GenBank/EMBL/DDBJ: DAA10251.1 \| AY558366 \| Z46259 \| Z71586

Amino Acid Sequence (or in FASTA format)
1 MIPRTRTLLQ SKIPITRYFA RCWAPRVRYN VCRTLPAAAL HTNIIAHNEV 51 KKDDKKVHLG SFKVDKPKMM IAFTCKKCNT RSSHTMSKQA YEKGTVLISC 101 PHCKVRHLIA DHLKIFHDHH VTVEQLMKAN GEQVSQDVGD LEFEDIPDSL 151 KDVLGKYAKN NSENASQLPH PSQK*

Amino Acid Sequence (or in FASTA format)

       1  MIPRTRTLLQ SKIPITRYFA RCWAPRVRYN VCRTLPAAAL HTNIIAHNEV
      51  KKDDKKVHLG SFKVDKPKMM IAFTCKKCNT RSSHTMSKQA YEKGTVLISC
     101  PHCKVRHLIA DHLKIFHDHH VTVEQLMKAN GEQVSQDVGD LEFEDIPDSL
     151  KDVLGKYAKN NSENASQLPH PSQK*

external links for Zim17p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Zim17p

1)	Burri L, et al. (2004) Zim17, a novel zinc finger protein essential for protein import into mitochondria. J Biol Chem 279(48):50243-9
2)	Yamamoto H, et al. (2005) Identification of a novel member of yeast mitochondrial Hsp70-associated motor and chaperone proteins that facilitates protein translocation across the inner membrane. FEBS Lett 579(2):507-11
3)	Sichting M, et al. (2005) Maintenance of structure and function of mitochondrial Hsp70 chaperones requires the chaperone Hep1. EMBO J 24(5):1046-56
4)	Sanjuan Szklarz LK, et al. (2005) Inactivation of the mitochondrial heat shock protein zim17 leads to aggregation of matrix hsp70s followed by pleiotropic effects on morphology and protein biogenesis. J Mol Biol 351(1):206-18
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41