BXI1/YNL305C Protein Information

Standard Name	Bxi1p 1
Systematic Name	Ynl305cp
Alias	Ybh3p 2
ORF Classification	Verified
Description	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole; may link the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p (1, 2, 3, 4, 5)
Name Description	BaX Inhibitor 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	297
Molecular Weight (Da)	33,645
Isoelectric Point (pI)	4.73

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Bxi1p (InterPro)
Transmembrane Domains	There are 7 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BA84 \| P48558 MIPS: YNL305C NCBI: 1050855 \| 1302403 \| 1353101 \| 51012809 \| 6324024 \| NP_014094.1 GenBank/EMBL/DDBJ: DAA10256.1 \| AY692679 \| U23084 \| Z71581

Amino Acid Sequence (or in FASTA format)
1 MSGPPPPYEE QSSHLYGQPA SSQDGNAFIP EDFKYSTVVI SCEPIIRQRF 51 MHKVYSLLSC QLLASLSFCY WASVSTSLQN FIMSHIALFY ICMVVSLVSC 101 IWLAVSPRPE DYEASVPEPL LTGSSEEPAQ EQRRLPWYVL SSYKQKLTLL 151 SIFTLSEAYC LSLVTLAYDK DTVLSALLIT TIVVVGVSLT ALSERFENVL 201 NSATSIYYWL NWGLWIMIGM GLTALLFGWN THSSKFNLLY GWLGAILFTA 251 YLFIDTQLIF RKVYPDEEVR CAMMLYLDIV NLFLSILRIL ANSNDDN*

Amino Acid Sequence (or in FASTA format)

       1  MSGPPPPYEE QSSHLYGQPA SSQDGNAFIP EDFKYSTVVI SCEPIIRQRF
      51  MHKVYSLLSC QLLASLSFCY WASVSTSLQN FIMSHIALFY ICMVVSLVSC
     101  IWLAVSPRPE DYEASVPEPL LTGSSEEPAQ EQRRLPWYVL SSYKQKLTLL
     151  SIFTLSEAYC LSLVTLAYDK DTVLSALLIT TIVVVGVSLT ALSERFENVL
     201  NSATSIYYWL NWGLWIMIGM GLTALLFGWN THSSKFNLLY GWLGAILFTA
     251  YLFIDTQLIF RKVYPDEEVR CAMMLYLDIV NLFLSILRIL ANSNDDN*

external links for Bxi1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Bxi1p

1)	Cebulski J, et al. (2011) Yeast Bax Inhibitor, Bxi1p, Is an ER-Localized Protein That Links the Unfolded Protein Response and Programmed Cell Death in Saccharomyces cerevisiae. PLoS One 6(6):e20882
2)	Buttner S, et al. (2011) A yeast BH3-only protein mediates the mitochondrial pathway of apoptosis.LID - 10.1038/emboj.2011.197 [doi] EMBO J ()
3)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
4)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
5)	Chae HJ, et al. (2003) Evolutionarily conserved cytoprotection provided by Bax Inhibitor-1 homologs from animals, plants, and yeast. Gene 323():101-13