CAF40/YNL288W Protein Information

Standard Name	Caf40p 1
Systematic Name	Ynl288wp
ORF Classification	Verified
Description	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p (1)
Name Description	CCR4 Associated Factor 1

Experimental Data
Molecules/cell	18800 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	373
Molecular Weight (Da)	41,155
Isoelectric Point (pI)	7.1

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Caf40p (InterPro)
Physical Interactions	There are 119 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E01 \| P53829 MIPS: YNL288W NCBI: 1302371 \| 1730650 \| 6324041 \| NP_014111.1 GenBank/EMBL/DDBJ: DAA10271.1 \| Z71564

Amino Acid Sequence (or in FASTA format)
1 MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG 51 GPMLMGNTPN NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA 101 LDDPNVYHWI CQLTYGPQKE QALLELGRKR EQFDDLAVVL WSSFGVMTSL 151 LNEIISVYPM LQPQMLSNNL SNRVCNALVL LQCVASHPET KHLFLQAHIP 201 LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT FLLRTDIVPL 251 CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM 301 VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV 351 LRDDVGSKRC LAQLLLTLNE ETS*

Amino Acid Sequence (or in FASTA format)

       1  MFSAQKPIYG NGAGVNMGGG GPSTNNPGSM SMPGVPTSMG PGMNQQIPSG
      51  GPMLMGNTPN NNNSNENGEN NGNNGNNGGN DANATRNNPN MVNNRGAVHA
     101  LDDPNVYHWI CQLTYGPQKE QALLELGRKR EQFDDLAVVL WSSFGVMTSL
     151  LNEIISVYPM LQPQMLSNNL SNRVCNALVL LQCVASHPET KHLFLQAHIP
     201  LFLFPFLNTT SRQRTFEYLR LTSLGVIGAL VKNDSQDVIT FLLRTDIVPL
     251  CLRIMESSSE LSKTVAIFIL QKILLDDVGL QYICATLERF YAVTNVLKDM
     301  VEHLTVSTPP GRLLKHIIRC YLRLSDDLEA RRLLKIVLPA KLRDNTFTEV
     351  LRDDVGSKRC LAQLLLTLNE ETS*

external links for Caf40p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Caf40p

1)	Chen J, et al. (2001) Purification and characterization of the 1.0 MDa CCR4-NOT complex identifies two novel components of the complex. J Mol Biol 314(4):683-94
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41