CUS2/YNL286W Protein Information

Standard Name	Cus2p
Systematic Name	Ynl286wp
ORF Classification	Verified
Description	Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) (1)
Name Description	Cold sensitive U2 snRNA Suppressor 1

Experimental Data
Molecules/cell	1360 2

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	285
Molecular Weight (Da)	32,284
Isoelectric Point (pI)	4.73

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Cus2p (InterPro)
Physical Interactions	There are 12 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BA75 \| P53830 MIPS: YNL286W NCBI: 1302367 \| 1730649 \| 45269922 \| 6324043 \| NP_014113.1 GenBank/EMBL/DDBJ: DAA10273.1 \| AY558016 \| Z71562

Amino Acid Sequence (or in FASTA format)
1 MDADELELKG HLKKLKKEEL LRRKQLKESN LQKRELEYNN ASKNTSIYIS 51 GLPTDKTTKE GLTEQFCKYG MIRTNRDGEP LCKLYVNDKG AFKGDALITY 101 SKEESVTLAI EMMNESIFLG KQIRVERAQF QNKEGDNMHG KENDLKEFNG 151 PEPPIKRLKK AKSEGEGEVI DYNDDESLAK ADRTVIFANV FNIYKSYTND 201 DINDIQEDLL EGCEEIGQVD SISVSPNKGE ATVVFKNNKV ALQCCKIMTG 251 RYFDGQKLLA FISGDENTSS TSDKNEDSEV EDDLI*

Amino Acid Sequence (or in FASTA format)

       1  MDADELELKG HLKKLKKEEL LRRKQLKESN LQKRELEYNN ASKNTSIYIS
      51  GLPTDKTTKE GLTEQFCKYG MIRTNRDGEP LCKLYVNDKG AFKGDALITY
     101  SKEESVTLAI EMMNESIFLG KQIRVERAQF QNKEGDNMHG KENDLKEFNG
     151  PEPPIKRLKK AKSEGEGEVI DYNDDESLAK ADRTVIFANV FNIYKSYTND
     201  DINDIQEDLL EGCEEIGQVD SISVSPNKGE ATVVFKNNKV ALQCCKIMTG
     251  RYFDGQKLLA FISGDENTSS TSDKNEDSEV EDDLI*

external links for Cus2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Cus2p

1)	Yan D, et al. (1998) CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. Mol Cell Biol 18(9):5000-9
2)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41