WSC2/YNL283C Protein Information Help

Standard Name Wsc2p
Systematic Name Ynl283cp
Alias Sta3p
ORF Classification Verified
Description Sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway; involved in maintenance of cell wall integrity and recovery from heat shock; required for the arrest of secretion response; WSC2 has a paralog, WSC3, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7, 8)
Name Description cell Wall integrity and Stress response Component 2
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 503
Molecular Weight (Da) 52,292
Isoelectric Point (pI) 6.95

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Wsc2p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 21 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000138F9E | P53832
MIPS: YNL283C
NCBI: 1302357 | 1730647 | 6324046 | NP_014116.1
GenBank/EMBL/DDBJ: DAA10277.1 | Z71559
Amino Acid Sequence (or in FASTA format)
 
       1  MHLDLIHKSF ILVWLIYIRA ALADQFTYKA CYSASDIRKL GLTYKGVYEY
      51  QSVSYCQNEC PGQAVVALFN GTGCYCGGSV AQLQSLTQVD SSKCDVSCAG
     101  WPYQNCGGSS AMNVYINNAA STADSTSSTA TSTSTTSSSS TSVSSKTSTK
     151  LDTKTSTSSS ATHSSSSSST TSTTTSSSET TTSSSSSSSS SSTSTTSTTS
     201  TTSSTTSTSS SPSTTSSSTS ASSSSETSST QATSSSTTST SSSTSTATVT
     251  STPSSTSIGT STHYTTRVVT QSVVSQANQQ ASTIFTTRTS VYATVSSTSS
     301  STSSLLNGKS SSSKSKGLSG GAIAGVVVGV VCGTVALLAL ALFFFVWKKR
     351  RQSSQHVDLE ETKQYQPYSL GDADANPVIP PSASSTNWHI PSRNNTALSK
     401  NTASTFATYD LPTRAPGGRD SIITGDAHNI SKRSHFPSVV YEEPPSIYNG
     451  NQRFSATSLP DMMEERQLHI VNPDNVSSNI GSNVSDGDDD YDDAKDSNNS
     501  SLR*

external links for Wsc2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

GeneMANIA

References cited on this page View Complete Literature Guide for Wsc2p
1) Raboy B, et al.  (1999) Heat-induced cell cycle arrest of Saccharomyces cerevisiae: involvement of the RAD6/UBC2 and WSC2 genes in its reversal. Mol Microbiol 32(4):729-39
2) Verna J, et al.  (1997) A family of genes required for maintenance of cell wall integrity and for the stress response in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(25):13804-9
3) Kosodo Y, et al.  (2001) Multicopy suppressors of the sly1 temperature-sensitive mutation in the ER-Golgi vesicular transport in Saccharomyces cerevisiae. Yeast 18(11):1003-14
4) Zu T, et al.  (2001) Mutations in WSC genes for putative stress receptors result in sensitivity to multiple stress conditions and impairment of Rlm1-dependent gene expression in Saccharomyces cerevisiae. Mol Genet Genomics 266(1):142-55
5) Nanduri J and Tartakoff AM  (2001) The arrest of secretion response in yeast: signaling from the secretory path to the nucleus via Wsc proteins and Pkc1p. Mol Cell 8(2):281-9
6) Ng DT  (2001) Interorganellar signal transduction: the arrest of secretion response. Dev Cell 1(3):319-20
7) Imazu H and Sakurai H  (2005) Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock. Eukaryot Cell 4(6):1050-6
8) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61