POP3/YNL282W Protein Information

Standard Name	Pop3p 1
Systematic Name	Ynl282wp
ORF Classification	Verified
Description	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs (1, 2, 3, 4)
Name Description	Processing Of Precursor RNAs 1

Experimental Data
Molecules/cell	1360 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	195
Molecular Weight (Da)	22,612
Isoelectric Point (pI)	10.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Pop3p (InterPro)
Physical Interactions	There are 40 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000131F37 \| P53833 MIPS: YNL282W NCBI: 1302355 \| 1419235 \| 1730646 \| 6324047 \| NP_014117.1 GenBank/EMBL/DDBJ: DAA10278.1 \| X95844 \| Z71558

Amino Acid Sequence (or in FASTA format)
1 MSGSLKSLDK KIAKRRQVYK PVLDNPFTNE AHMWPRVHDQ PLIWQLLQSS 51 IINKLIHIQS KENYPWELYT DFNEIVQYLS GAHGNSDPVC LFVCNKDPDV 101 PLVLLQQIPL LCYMAPMTVK LVQLPKSAMD TFKSVSKYGM LLLRCDDRVD 151 KKFVSQIQKN VDLLQFPWLN AIKYRPTSVK LLKTTVPIVS KKRQK*

Amino Acid Sequence (or in FASTA format)

       1  MSGSLKSLDK KIAKRRQVYK PVLDNPFTNE AHMWPRVHDQ PLIWQLLQSS
      51  IINKLIHIQS KENYPWELYT DFNEIVQYLS GAHGNSDPVC LFVCNKDPDV
     101  PLVLLQQIPL LCYMAPMTVK LVQLPKSAMD TFKSVSKYGM LLLRCDDRVD
     151  KKFVSQIQKN VDLLQFPWLN AIKYRPTSVK LLKTTVPIVS KKRQK*

external links for Pop3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome
YOGY	DIP
	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Pop3p

1)	Dichtl B and Tollervey D (1997) Pop3p is essential for the activity of the RNase MRP and RNase P ribonucleoproteins in vivo. EMBO J 16(2):417-29
2)	Chamberlain JR, et al. (1998) Purification and characterization of the nuclear RNase P holoenzyme complex reveals extensive subunit overlap with RNase MRP. Genes Dev 12(11):1678-90
3)	Houser-Scott F, et al. (2002) Interactions among the protein and RNA subunits of Saccharomyces cerevisiae nuclear RNase P. Proc Natl Acad Sci U S A 99(5):2684-9
4)	Marvin MC, et al. (2011) Accumulation of noncoding RNA due to an RNase P defect in Saccharomyces cerevisiae. RNA 17(8):1441-50
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41