SEC2/YNL272C Protein Information Help

Standard Name Sec2p 1, 2
Systematic Name Ynl272cp
ORF Classification Verified
Description Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles (3, 4, 5)
Name Description SECretory 1
Experimental Data
Molecules/cell 13200 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 759
Molecular Weight (Da) 84,651
Isoelectric Point (pI) 4.86

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sec2p (InterPro)
Physical Interactions There are 110 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013574D | P17065
MIPS: YNL272C
NCBI: 1302336 | 134104227 | 134104228 | 134104229 | 134104230 | 134104231 | 134104232 | 134104233 | 134104234 | 134104235 | 134104236 | 134104237 | 134104238 | 134104239 | 134104240 | 134104241 | 134104242 | 134104243 | 134104244 | 134104245 | 134104246 | 134105121 | 134105122 | 134393 | 149241640 | 149241641 | 4439 | 6324057 | NP_014127.1 | NM_001183110.1
GenBank/EMBL/DDBJ: DAA10288.1 | X52147 | Z71548
Amino Acid Sequence (or in FASTA format)
 
       1  MDASEEAKRV SIQVTSLSTQ LIESVDKQSH LEEQLNKSLK TIASQKAAIE
      51  NYNQLKEDYN TLKRELSDRD DEVKRLREDI AKENELRTKA EEEADKLNKE
     101  VEDLTASLFD EANNMVADAR KEKYAIEILN KRLTEQLREK DTLLDTLTLQ
     151  LKNLKKVMHS LDNESTVTNN SNRYSTILSD SATSSSTSLN KVPTSYSLAS
     201  QDIYSGIVYS PSISSIRYDI SLYNEFLKFV AALPRCENIK ATSTESKLIR
     251  RLVNDEIQPI LKIDNASGIG WLVKKTLLSL IIDGLVVVEP LSGVNATYQI
     301  GYNSSSPAKQ ATSNMPKMFK FPLDSPPVAV HAACSFCGES RDDIIEHARM
     351  YILKTLHKTD DGKEQVTNTY PLCHWCLLKL RQTCEIFAFL RSLKVGAWHL
     401  EKLTTQNITK EDLEKFSEVT KHTKRDGRVS SQDKKTKRLS FMAGLGINSS
     451  TKNKPKMEIF SSETNAKPGQ PTTNIQRAWL QLCKLRCILH WTHIGIWAVD
     501  DSISSKIGPL VEDDSDEDQN DAISVRLQDK ALWKQDAKRP FSSSSAEESQ
     551  KSDAFDFESG DMENEITGES SSDESSSDGS STDNSTADSS SEDESSLADS
     601  TTSSADSSSP ESIDNGEGDD TVTKDDKSSI KSANNNEENS DCGDKKGRSI
     651  IKKKAPQRKI QKKKLLQDLD DLEEQFREES AIDQTEFENA ESNVKQNISS
     701  KRASSGDENS KKDNNEKTLK TNLTIGDKTQ EQIGENSPSS GLHASSSNDD
     751  NFDDAQEQQ*

external links for Sec2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sec2p
1) Novick P, et al.  (1980) Identification of 23 complementation groups required for post-translational events in the yeast secretory pathway. Cell 21(1):205-15
2) Fields, C. and Schekman, R.  (1985) Personal Communication, Mortimer Map Edition 9
3) Walch-Solimena C, et al.  (1997) Sec2p mediates nucleotide exchange on Sec4p and is involved in polarized delivery of post-Golgi vesicles. J Cell Biol 137(7):1495-509
4) Medkova M, et al.  (2006) The rab exchange factor Sec2p reversibly associates with the exocyst. Mol Biol Cell 17(6):2757-69
5) Geng J, et al.  (2010) Post-golgi sec proteins are required for autophagy in Saccharomyces cerevisiae. Mol Biol Cell 21(13):2257-69
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41