PIK1/YNL267W Protein Information Help

Standard Name Pik1p 1
Systematic Name Ynl267wp
Alias Pik41p 2 , Pik120p 2
ORF Classification Verified
Description Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton (1, 3)
Name Description Phosphatidyl Inositol Kinase 1
Experimental Data
Molecules/cell 1600 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,066
Molecular Weight (Da) 119,922
Isoelectric Point (pI) 6.46

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Pik1p (InterPro)
Physical Interactions There are 40 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052EA4 | P39104
MIPS: YNL267W
NCBI: 1045243 | 1302326 | 187609437 | 432496 | 433917 | 6324062 | 730327 | NP_014132.1
GenBank/EMBL/DDBJ: DAA10293.1 | L20220 | X76058 | X92494 | Z71543
External Classifications EC: 2.7.1.67 [1-phosphatidylinositol 4-kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MHKASSSKKS FDDTIELKKN EQLLKLINSS EFTLHNCVEL LCKHSENIGI
      51  HYYLCQKLAT FPHSELQFYI PQLVQVLVTM ETESMALEDL LLRLRAENPH
     101  FALLTFWQLQ ALLTDLSTDP ASYGFQVARR VLNNLQTNLF NTSSGSDKNV
     151  KIHENVAPAL VLSSMIMSAI AFPQLSEVTK PLVESQGRRQ KAFVFKLARS
     201  AMKDFTKNMT LKNTLLNKKT SRSKRVSSNR SSTPTSPIDL IDPIKTKEDA
     251  SFRKSRHSEV KLDFDIVDDI GNQVFEERIS SSIKLPKRKP KYLDNSYVHR
     301  TYDGKNINRD GSISNTAKAL DGNKGDYISP KGRNDENNEI GNNEDETGGE
     351  TEEDADALNS DHFTSSMPDL HNIQPRTSSA SSASLEGTPK LNRTNSQPLS
     401  RQAFKNSKKA NSSLSQEIDL SQLSTTSKIK MLKANYFRCE TQFAIALETI
     451  SQRLARVPTE ARLSALRAEL FLLNRDLPAE VDIPTLLPPN KKGKLHKLVT
     501  ITANEAQVLN SAEKVPYLLL IEYLRDEFDF DPTSETNERL LKKISGNQGG
     551  LIFDLNYMNR KENNENRNES TLTSNNTRSS VYDSNSFNNG ASRNEGLSST
     601  SRSDSASTAH VRTEVNKEED LGDMSMVKVR NRTDDEAYRN ALVIQSAANV
     651  PILPDDSQDR SPELNFGSNL DEVLIENGIN SKNIHSQTDA LADQMRVSAV
     701  MLAQLDKSPQ QLSESTKQIR AQIISSMKEV QDKFGYHDLE ALHGMAGERK
     751  LENDLMTGGI DTSYLGEDWA TKKERIRKTS EYGHFENWDL CSVIAKTGDD
     801  LRQEAFAYQM IQAMANIWVK EKVDVWVKRM KILITSANTG LVETITNAMS
     851  VHSIKKALTK KMIEDAELDD KGGIASLNDH FLRAFGNPNG FKYRRAQDNF
     901  ASSLAAYSVI CYLLQVKDRH NGNIMIDNEG HVSHIDFGFM LSNSPGSVGF
     951  EAAPFKLTYE YIELLGGVEG EAFKKFVELT KSSFKALRKY ADQIVSMCEI
    1001  MQKDNMQPCF DAGEQTSVQL RQRFQLDLSE KEVDDFVENF LIGKSLGSIY
    1051  TRIYDQFQLI TQGIYS*

external links for Pik1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CandidaDB) CYC2008 (complexes) Pfam domains
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Pik1p
1) Flanagan CA, et al.  (1993) Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science 262(5138):1444-8
2) Hunter T and Plowman GD  (1997) The protein kinases of budding yeast: six score and more. Trends Biochem Sci 22(1):18-22
3) Garcia-Bustos JF, et al.  (1994) PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J 13(10):2352-61
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41