ORC5/YNL261W Protein Information

Standard Name	Orc5p
Systematic Name	Ynl261wp
ORF Classification	Verified
Description	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing (1)
Name Description	Origin Recognition Complex 2

Experimental Data
Molecules/cell	768 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	479
Molecular Weight (Da)	55,289
Isoelectric Point (pI)	5.77

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Orc5p (InterPro)
Physical Interactions	There are 96 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000531B4 \| P50874 MIPS: YNL261W NCBI: 1255957 \| 1302315 \| 1709491 \| 6324068 \| 841421 \| NP_014138.1 \| NM_001183099.1 GenBank/EMBL/DDBJ: DAA10298.1 \| U24187 \| X96722 \| Z71537

Amino Acid Sequence (or in FASTA format)
1 MNVTTPEVAF REYQTNCLAS YISADPDITP SNLILQGYSG TGKTYTLKKY 51 FNANPNLHAV WLEPVELVSW KPLLQAIART VQYKLKTLYP NIPTTDYDPL 101 QVEEPFLLVK TLHNIFVQYE SLQEKTCLFL ILDGFDSLQD LDAALFNKYI 151 KLNELLPKDS KINIKFIYTM LETSFLQRYS THCIPTVMFP RYNVDEVSTI 201 LVMSRCGELM EDSCLRKRII EEQITDCTDD QFQNVAANFI HLIVQAFHSY 251 TGNDIFALND LIDFKWPKYV SRITKENIFE PLALYKSAIK LFLSTDDNLS 301 ENGQGESAIT TNRDDLENSQ TYDLSIISKY LLIASYICSY LEPRYDASIF 351 SRKTRIIQGR AAYGRRKKKE VNPRYLQPSL FAIERLLAIF QAIFPIQGKA 401 ESGSLSALRE ESLMKANIEV FQNLSELHTL KLIATTMNKN IDYLSPKVRW 451 KVNVPWEIIK EISESVHFNI SDYFSDIHE*

Amino Acid Sequence (or in FASTA format)

       1  MNVTTPEVAF REYQTNCLAS YISADPDITP SNLILQGYSG TGKTYTLKKY
      51  FNANPNLHAV WLEPVELVSW KPLLQAIART VQYKLKTLYP NIPTTDYDPL
     101  QVEEPFLLVK TLHNIFVQYE SLQEKTCLFL ILDGFDSLQD LDAALFNKYI
     151  KLNELLPKDS KINIKFIYTM LETSFLQRYS THCIPTVMFP RYNVDEVSTI
     201  LVMSRCGELM EDSCLRKRII EEQITDCTDD QFQNVAANFI HLIVQAFHSY
     251  TGNDIFALND LIDFKWPKYV SRITKENIFE PLALYKSAIK LFLSTDDNLS
     301  ENGQGESAIT TNRDDLENSQ TYDLSIISKY LLIASYICSY LEPRYDASIF
     351  SRKTRIIQGR AAYGRRKKKE VNPRYLQPSL FAIERLLAIF QAIFPIQGKA
     401  ESGSLSALRE ESLMKANIEV FQNLSELHTL KLIATTMNKN IDYLSPKVRW
     451  KVNVPWEIIK EISESVHFNI SDYFSDIHE*

external links for Orc5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Orc5p

1)	Bell SP (2002) The origin recognition complex: from simple origins to complex functions. Genes Dev 16(6):659-72
2)	Bell SP and Stillman B (1992) ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complex. Nature 357(6374):128-34
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41