KEX2/YNL238W Protein Information Help

Standard Name Kex2p 1
Systematic Name Ynl238wp
Alias Qds1p , Vma45p , Srb1p 2
ORF Classification Verified
Description Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway (3)
Name Description Killer EXpression defective
Gene Product kexin , yscF 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 814
Molecular Weight (Da) 90,002
Isoelectric Point (pI) 4.67

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Kex2p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Signal Peptide(s) There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions There are 29 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012DDA0 | P13134
MIPS: YNL238W
NCBI: 1183976 | 125350 | 1302270 | 146386533 | 146386534 | 171781 | 33357783 | 33357784 | 47168726 | 47168727 | 531007 | 6324091 | NP_014161.1
GenBank/EMBL/DDBJ: DAA10321.1 | M22870 | M24201 | Z69381 | Z71514
External Classifications EC: 3.4.21.61 [Kexin]
Amino Acid Sequence (or in FASTA format)
 
       1  MKVRKYITLC FWWAFSTSAL VSSQQIPLKD HTSRQYFAVE SNETLSRLEE
      51  MHPNWKYEHD VRGLPNHYVF SKELLKLGKR SSLEELQGDN NDHILSVHDL
     101  FPRNDLFKRL PVPAPPMDSS LLPVKEAEDK LSINDPLFER QWHLVNPSFP
     151  GSDINVLDLW YNNITGAGVV AAIVDDGLDY ENEDLKDNFC AEGSWDFNDN
     201  TNLPKPRLSD DYHGTRCAGE IAAKKGNNFC GVGVGYNAKI SGIRILSGDI
     251  TTEDEAASLI YGLDVNDIYS CSWGPADDGR HLQGPSDLVK KALVKGVTEG
     301  RDSKGAIYVF ASGNGGTRGD NCNYDGYTNS IYSITIGAID HKDLHPPYSE
     351  GCSAVMAVTY SSGSGEYIHS SDINGRCSNS HGGTSAAAPL AAGVYTLLLE
     401  ANPNLTWRDV QYLSILSAVG LEKNADGDWR DSAMGKKYSH RYGFGKIDAH
     451  KLIEMSKTWE NVNAQTWFYL PTLYVSQSTN STEETLESVI TISEKSLQDA
     501  NFKRIEHVTV TVDIDTEIRG TTTVDLISPA GIISNLGVVR PRDVSSEGFK
     551  DWTFMSVAHW GENGVGDWKI KVKTTENGHR IDFHSWRLKL FGESIDSSKT
     601  ETFVFGNDKE EVEPAATEST VSQYSASSTS ISISATSTSS ISIGVETSAI
     651  PQTTTASTDP DSDPNTPKKL SSPRQAMHYF LTIFLIGATF LVLYFMFFMK
     701  SRRRIRRSRA ETYEFDIIDT DSEYDSTLDN GTSGITEPEE VEDFDFDLSD
     751  EDHLASLSSS ENGDAEHTID SVLTNENPFS DPIKQKFPND ANAESASNKL
     801  QELQPDVPPS SGRS*

external links for Kex2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Kex2p
1) Link, A. and Olson, M.  (1989) Personal Communication, Mortimer Map Edition 10
2) Martin C and Young RA  (1989) KEX2 mutations suppress RNA polymerase II mutants and alter the temperature range of yeast cell growth. Mol Cell Biol 9(6):2341-9
3) Fuller RS, et al.  (1989) Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. Proc Natl Acad Sci U S A 86(5):1434-8
4) Seeboth PG and Heim J  (1991) In-vitro processing of yeast alpha-factor leader fusion proteins using a soluble yscF (Kex2) variant. Appl Microbiol Biotechnol 35(6):771-6