MGS1/YNL218W Protein Information Help

Standard Name Mgs1p 1
Systematic Name Ynl218wp
ORF Classification Verified
Description Protein with DNA-dependent ATPase and ssDNA annealing activities; involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP); forms nuclear foci upon DNA replication stress (1, 2, 3, 4)
Name Description Maintenance of Genome Stability 1
Experimental Data
Molecules/cell 1180 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 587
Molecular Weight (Da) 66,543
Isoelectric Point (pI) 8.47

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mgs1p (InterPro)
Physical Interactions There are 18 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000053292 | P40151
MIPS: YNL218W
NCBI: 1302233 | 1730822 | 2253183 | 51013831 | 600046 | 6324111 | NP_014181.1 | NM_001183056.1
GenBank/EMBL/DDBJ: DAA10338.1 | AY693190 | X78898 | Z71493 | Z71494
Amino Acid Sequence (or in FASTA format)
 
       1  MSNKRTSVEQ LISCPICSRK VFFSLINSHL DICGKEKSKP SSRPQTVSSL
      51  LAGPKKRKQA NSEKFIDLEN KDHEIKPGLK SESDDIEIVE NESKRFKAAP
     101  STDFAKSIVE PASSRDQLHN DYESRWLQKI SHLPLSEKLR PKELRDYVGQ
     151  QHILSQDNGT LFKYIKQGTI PSMILWGPPG VGKTSLARLL TKTATTSSNE
     201  SNVGSRYFMI ETSATKANTQ ELRGIFEKSK KEYQLTKRRT VLFIDEIHRF
     251  NKVQQDLLLP HVENGDIILI GATTENPSFQ LNNALISRCL IFVLEKLNVN
     301  ELCIVLSRGI ALLNKCRKQV WNIENPLKLS RSILEYVVDL SVGDTRRALN
     351  MLEMIEVSTR ERKADEEELS IDDVRDIIKN NSSNGLNTYY DPKGDNHYDT
     401  ISAFHKSIRG GDENASLYYL ARMLQGGEDP LYVARRMIRI ASEDIGLRDS
     451  SLLPLAVAAH DAVMKVGLPE ADLALAQCCV ALARAPKSVE LYRAWKKLRA
     501  MMSENMYSLA SSEIPMHIRN APTKLMEELG YHKGYKYNPD YIEGKVQQDY
     551  FPKEVLEKCP NKTDLKFLDG KHLGDKEDPD LRQSYQG*

external links for Mgs1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mgs1p
1) Hishida T, et al.  (2001) A yeast gene, MGS1, encoding a DNA-dependent AAA(+) ATPase is required to maintain genome stability. Proc Natl Acad Sci U S A 98(15):8283-9
2) Hishida T, et al.  (2002) Saccharomyces cerevisiae MGS1 is essential in strains deficient in the RAD6-dependent DNA damage tolerance pathway. EMBO J 21(8):2019-29
3) Branzei D, et al.  (2002) The product of Saccharomyces cerevisiae WHIP/MGS1, a gene related to replication factor C genes, interacts functionally with DNA polymerase delta. Mol Genet Genomics 268(3):371-86
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41