YNL194C Protein Information

Systematic Name	Ynl194cp
ORF Classification	Verified
Description	Integral membrane protein; required for sporulation and plasma membrane sphingolipid content; similar to SUR7; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; GFP-fusion protein is more abundant at MCCs (membrane compartment occupied by Can1) in the presence of glycerol and oleate; YNL194C has a paralog, FMP45, that arose from the whole genome duplication (1, 2, 3, 4, 5)

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	301
Molecular Weight (Da)	34,081
Isoelectric Point (pI)	10.63

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ynl194cp (InterPro)
Transmembrane Domains	There are 4 total predicted transmembrane domains (TMHMM)
Signal Peptide(s)	There are 1 total predicted predicted signal peptide(s) (SignalP)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BBAF \| P40169 MIPS: YNL194C NCBI: 1302189 \| 600071 \| 6324135 \| 732199 \| NP_014205.1 GenBank/EMBL/DDBJ: DAA10359.1 \| X78898 \| Z71470

Amino Acid Sequence (or in FASTA format)
1 MSYKKFVYFI NLFFLLGATL LTFFLILAGG RTTGVLKNFY WFQASTSGFN 51 SAPSVTRWYN YNWCGWESRG IAVNCSSKMA AQPFSPRDNF GSSPLMPSTF 101 LNNRNAYYYL SRVGWAMLLI GLFFLLITLV SVIASLIRYN RRTAALATAM 151 SWITLFFITL SACLYTGCYA KAVKAFHHEN RDARLGPKNF GLIWTTVFLL 201 IVNAICCTIM VATHKRNEYI YDRSFASTKT VDSQTPTPVP TNGGIPSSVP 251 VTEVQQSQSH QNHRFFKKLR TKKRTVTSAG DEPDRVQEER VYTEQNVPVV 301 S*

Amino Acid Sequence (or in FASTA format)

       1  MSYKKFVYFI NLFFLLGATL LTFFLILAGG RTTGVLKNFY WFQASTSGFN
      51  SAPSVTRWYN YNWCGWESRG IAVNCSSKMA AQPFSPRDNF GSSPLMPSTF
     101  LNNRNAYYYL SRVGWAMLLI GLFFLLITLV SVIASLIRYN RRTAALATAM
     151  SWITLFFITL SACLYTGCYA KAVKAFHHEN RDARLGPKNF GLIWTTVFLL
     201  IVNAICCTIM VATHKRNEYI YDRSFASTKT VDSQTPTPVP TNGGIPSSVP
     251  VTEVQQSQSH QNHRFFKKLR TKKRTVTSAG DEPDRVQEER VYTEQNVPVV
     301  S*

external links for Ynl194cp

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ynl194cp

1)	Young ME, et al. (2002) The Sur7p family defines novel cortical domains in Saccharomyces cerevisiae, affects sphingolipid metabolism, and is involved in sporulation. Mol Cell Biol 22(3):927-34
2)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
3)	Walther TC, et al. (2006) Eisosomes mark static sites of endocytosis. Nature 439(7079):998-1003
4)	Lee MW, et al. (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
5)	Jung S, et al. (2013) Global Analysis of Condition-specific Subcellular Protein Distribution and Abundance. Mol Cell Proteomics 12(5):1421-35