SWT21/YNL187W Protein Information

Standard Name	Swt21p 1
Systematic Name	Ynl187wp
ORF Classification	Verified
Description	Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats (1, 2, 3)
Name Description	Synthetic With Tgs1 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	357
Molecular Weight (Da)	40,307
Isoelectric Point (pI)	7.75

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Swt21p (InterPro)
Physical Interactions	There are 8 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000052E6E \| P53873 MIPS: YNL187W NCBI: 1302175 \| 1730815 \| 6324142 \| NP_014212.1 GenBank/EMBL/DDBJ: DAA10366.1 \| Z71463

Amino Acid Sequence (or in FASTA format)
1 MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF 51 TRFFRNQSIV SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG 101 QCILSYDTMN KINGEYETVY SVKIDVESRV YTGSCRNKVA IYDKSRRDAV 151 WMNQSTKKAS KGRQSIISCF EEQPMGGQAL SRGSLLCGSY ANEMFQVDCR 201 HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS IYDRRNLQHE 251 LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP 301 SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI 351 SLCRFGG*

Amino Acid Sequence (or in FASTA format)

       1  MEKKVICQDI FWSCDGTSFV SVHNDFGIRQ YLVPEESNTD KLNRNLLLPF
      51  TRFFRNQSIV SCAIDPFYTL YNENSDRLAG DRIVVGGKNF PLQLYSLMDG
     101  QCILSYDTMN KINGEYETVY SVKIDVESRV YTGSCRNKVA IYDKSRRDAV
     151  WMNQSTKKAS KGRQSIISCF EEQPMGGQAL SRGSLLCGSY ANEMFQVDCR
     201  HQRLERLNYT RTVAGGIVQI LTSDNGRYVY VVRRNSDAIS IYDRRNLQHE
     251  LNVLRLPFRI HHNSAKLKAY IDTAYGLSMG TPQGTILNWG RDLVEFGGVP
     301  SHNSVEDPLI TSIPPESEWR TNLDSTIPAT VVKNCPGDPE LFALSHGGTI
     351  SLCRFGG*

external links for Swt21p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Swt21p

1)	Hausmann S, et al. (2008) Genetic and Biochemical Analysis of Yeast and Human Cap Trimethylguanosine Synthase: FUNCTIONAL OVERLAP OF 2,2,7-TRIMETHYLGUANOSINE CAPS, SMALL NUCLEAR RIBONUCLEOPROTEIN COMPONENTS, PRE-mRNA SPLICING FACTORS, AND RNA DECAY PATHWAYS. J Biol Chem 283(46):31706-18
2)	Murphy MW, et al. (2004) The yeast splicing factor Prp40p contains functional leucine-rich nuclear export signals that are essential for splicing. Genetics 166(1):53-65
3)	Hage R, et al. (2009) A targeted bypass screen identifies Ynl187p, Prp42p, Snu71p, and Cbp80p for stable U1 snRNP/Pre-mRNA interaction. Mol Cell Biol 29(14):3941-52