RHO5/YNL180C Protein Information

Standard Name	Rho5p
Systematic Name	Ynl180cp
Alias	Yns0p 1
ORF Classification	Verified
Description	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity (2, 3)
Name Description	Ras HOmolog 4

Experimental Data
Molecules/cell	2180 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	331
Molecular Weight (Da)	36,818
Isoelectric Point (pI)	8.66

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rho5p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BBA9 \| P53879 MIPS: YNL180C NCBI: 2253181 \| 2829437 \| 6324149 \| NP_014219.1 \| NM_001183018.1 GenBank/EMBL/DDBJ: DAA10372.1 \| Z71456

Amino Acid Sequence (or in FASTA format)
1 MRSIKCVIIG DGAVGKTSLL ISYTTNSFPT DYVPTVFDNY STTIAIPNGT 51 ASSPLELDNG NDKRGSLSSA SSSPSTDRKL YKINLWDTAG QEDYDRLRPL 101 CYPQTDIFLI CFSVSEHASF ANVTEKWLPE LKQTSNIEGT SLYTKLGKYP 151 ILLVGTKSDL RDDPATQKKL QEANSDYVSQ EEIDELVQRC GFMGYTECSA 201 ATQAGVREVF EQAVRYAIYE PESPNQKSAN HTLTDELTTA TTNTNGDKNI 251 REQKQQPHHN NSTDSTLPKG SLQQEKEALN IKPTKKGQKD KIHEQSKSKG 301 SKIASNNHHN KQAKPKTRND KKKKKSKCVI L*

Amino Acid Sequence (or in FASTA format)

       1  MRSIKCVIIG DGAVGKTSLL ISYTTNSFPT DYVPTVFDNY STTIAIPNGT
      51  ASSPLELDNG NDKRGSLSSA SSSPSTDRKL YKINLWDTAG QEDYDRLRPL
     101  CYPQTDIFLI CFSVSEHASF ANVTEKWLPE LKQTSNIEGT SLYTKLGKYP
     151  ILLVGTKSDL RDDPATQKKL QEANSDYVSQ EEIDELVQRC GFMGYTECSA
     201  ATQAGVREVF EQAVRYAIYE PESPNQKSAN HTLTDELTTA TTNTNGDKNI
     251  REQKQQPHHN NSTDSTLPKG SLQQEKEALN IKPTKKGQKD KIHEQSKSKG
     301  SKIASNNHHN KQAKPKTRND KKKKKSKCVI L*

external links for Rho5p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Rho5p

1)	Garcia-Ranea JA and Valencia A (1998) Distribution and functional diversification of the ras superfamily in Saccharomyces cerevisiae. FEBS Lett 434(3):219-25
2)	Ridley AJ (1995) Rho-related proteins: actin cytoskeleton and cell cycle. Curr Opin Genet Dev 5(1):24-30
3)	Schmitz HP, et al. (2002) Rho5p downregulates the yeast cell integrity pathway. J Cell Sci 115(Pt 15):3139-48
4)	Roumanie O, et al. (2001) Functional characterization of the Bag7, Lrg1 and Rgd2 RhoGAP proteins from Saccharomyces cerevisiae. FEBS Lett 506(2):149-56
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41