RPS3/YNL178W Protein Information

Standard Name	Rps3p
Systematic Name	Ynl178wp
Alias	Suf14p
ORF Classification	Verified
Description	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; homologous to mammalian ribosomal protein S3 and bacterial S3 (1, 2, 3, 4, 5)
Name Description	Ribosomal Protein of the Small subunit
Gene Product	S3 2, 5 , YS3 2 , rp13 2

Experimental Data
Molecules/cell	146000 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	240
Molecular Weight (Da)	26,503
Isoelectric Point (pI)	10.22

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rps3p (InterPro)
Physical Interactions	There are 172 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C8D \| P05750 MIPS: YNL178W NCBI: 1173255 \| 1302158 \| 1463121 \| 313103665 \| 315113450 \| 315113478 \| 364506099 \| 364506137 \| 398364505 \| 457164 \| 468426 \| 49258823 \| NP_014221.3 GenBank/EMBL/DDBJ: DAA10373.1 \| D25285 \| L31405 \| U34347 \| Z71454

Amino Acid Sequence (or in FASTA format)
1 MVALISKKRK LVADGVFYAE LNEFFTRELA EEGYSGVEVR VTPTKTEVII 51 RATRTQDVLG ENGRRINELT LLVQKRFKYA PGTIVLYAER VQDRGLSAVA 101 QAESMKFKLL NGLAIRRAAY GVVRYVMESG AKGCEVVVSG KLRAARAKAM 151 KFADGFLIHS GQPVNDFIDT ATRHVLMRQG VLGIKVKIMR DPAKSRTGPK 201 ALPDAVTIIE PKEEEPILAP SVKDYRPAEE TEAQAEPVEA *

Amino Acid Sequence (or in FASTA format)

       1  MVALISKKRK LVADGVFYAE LNEFFTRELA EEGYSGVEVR VTPTKTEVII
      51  RATRTQDVLG ENGRRINELT LLVQKRFKYA PGTIVLYAER VQDRGLSAVA
     101  QAESMKFKLL NGLAIRRAAY GVVRYVMESG AKGCEVVVSG KLRAARAKAM
     151  KFADGFLIHS GQPVNDFIDT ATRHVLMRQG VLGIKVKIMR DPAKSRTGPK
     201  ALPDAVTIIE PKEEEPILAP SVKDYRPAEE TEAQAEPVEA *

external links for Rps3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Rps3p

1)	Fingen-Eigen M, et al. (1996) The ribosomal protein gene RPS3 is an essential single copy gene of the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 223(2):397-403
2)	Planta RJ and Mager WH (1998) The list of cytoplasmic ribosomal proteins of Saccharomyces cerevisiae. Yeast 14(5):471-7
3)	Jung SO, et al. (2001) Yeast ribosomal protein S3 has an endonuclease activity on AP DNA. Mol Cells 12(1):84-90
4)	Lecompte O, et al. (2002) Comparative analysis of ribosomal proteins in complete genomes: an example of reductive evolution at the domain scale. Nucleic Acids Res 30(24):5382-90
5)	Jenner L, et al. (2012) Crystal structure of the 80S yeast ribosome. Curr Opin Struct Biol 22(6):759-67
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41