SKO1/YNL167C Protein Information

Standard Name	Sko1p 1
Systematic Name	Ynl167cp
Alias	Acr1p 2
ORF Classification	Verified
Description	Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses (1, 3, 4, 5, 6, 7)
Name Description	Suppressor of Kinase Overexpression 1

Experimental Data
Molecules/cell	504 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	647
Molecular Weight (Da)	70,191
Isoelectric Point (pI)	10.09

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sko1p (InterPro)
Physical Interactions	There are 29 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001359E4 \| Q02100 MIPS: YNL167C NCBI: 1050786 \| 1302140 \| 260564 \| 401087 \| 4476 \| 6324162 \| NP_014232.1 GenBank/EMBL/DDBJ: DAA10381.1 \| S49588 \| X67875 \| X92517 \| Z71443

Amino Acid Sequence (or in FASTA format)
1 MSSEERSRQP STVSTFDLEP NPFEQSFASS KKALSLPGTI SHPSLPKELS 51 RNNSTSTITQ HSQRSTHSLN SIPEENGNST VTDNSNHNDV KKDSPSFLPG 101 QQRPTIISPP ILTPGGSKRL PPLLLSPSIL YQANSTTNPS QNSHSVSVSN 151 SNPSAIGVSS TSGSLYPNSS SPSGTSLIRQ PRNSNVTTSN SGNGFPTNDS 201 QMPGFLLNLS KSGLTPNESN IRTGLTPGIL TQSYNYPVLP SINKNTITGS 251 KNVNKSVTVN GSIENHPHVN IMHPTVNGTP LTPGLSSLLN LPSTGVLANP 301 VFKSTPTTNT TDGTVNNSIS NSNFSPNTST KAAVKMDNPA EFNAIEHSAH 351 NHKENENLTT QIENNDQFNN KTRKRKRRMS STSSTSKASR KNSISRKNSA 401 VTTAPAQKDD VENNKISNNV TLDENEEQER KRKEFLERNR VAASKFRKRK 451 KEYIKKIEND LQFYESEYDD LTQVIGKLCG IIPSSSSNSQ FNVNVSTPSS 501 SSPPSTSLIA LLESSISRSD YSSAMSVLSN MKQLICETNF YRRGGKNPRD 551 DMDGQEDSFN KDTNVVKSEN AGYPSVNSRP IILDKKYSLN SGANISKSNT 601 TTNNVGNSAQ NIINSCYSVT NPLVINANSD THDTNKHDVL STLPHNN*

Amino Acid Sequence (or in FASTA format)

       1  MSSEERSRQP STVSTFDLEP NPFEQSFASS KKALSLPGTI SHPSLPKELS
      51  RNNSTSTITQ HSQRSTHSLN SIPEENGNST VTDNSNHNDV KKDSPSFLPG
     101  QQRPTIISPP ILTPGGSKRL PPLLLSPSIL YQANSTTNPS QNSHSVSVSN
     151  SNPSAIGVSS TSGSLYPNSS SPSGTSLIRQ PRNSNVTTSN SGNGFPTNDS
     201  QMPGFLLNLS KSGLTPNESN IRTGLTPGIL TQSYNYPVLP SINKNTITGS
     251  KNVNKSVTVN GSIENHPHVN IMHPTVNGTP LTPGLSSLLN LPSTGVLANP
     301  VFKSTPTTNT TDGTVNNSIS NSNFSPNTST KAAVKMDNPA EFNAIEHSAH
     351  NHKENENLTT QIENNDQFNN KTRKRKRRMS STSSTSKASR KNSISRKNSA
     401  VTTAPAQKDD VENNKISNNV TLDENEEQER KRKEFLERNR VAASKFRKRK
     451  KEYIKKIEND LQFYESEYDD LTQVIGKLCG IIPSSSSNSQ FNVNVSTPSS
     501  SSPPSTSLIA LLESSISRSD YSSAMSVLSN MKQLICETNF YRRGGKNPRD
     551  DMDGQEDSFN KDTNVVKSEN AGYPSVNSRP IILDKKYSLN SGANISKSNT
     601  TTNNVGNSAQ NIINSCYSVT NPLVINANSD THDTNKHDVL STLPHNN*

external links for Sko1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
YGOB	CYC2008 (complexes)	Pfam domains
YOGY	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sko1p

1)	Nehlin JO, et al. (1992) Yeast SKO1 gene encodes a bZIP protein that binds to the CRE motif and acts as a repressor of transcription. Nucleic Acids Res 20(20):5271-8
2)	Vincent AC and Struhl K (1992) ACR1, a yeast ATF/CREB repressor. Mol Cell Biol 12(12):5394-405
3)	Rep M, et al. (2001) The Saccharomyces cerevisiae Sko1p transcription factor mediates HOG pathway-dependent osmotic regulation of a set of genes encoding enzymes implicated in protection from oxidative damage. Mol Microbiol 40(5):1067-83
4)	Serrano R and Rodriguez-Navarro A (2001) Ion homeostasis during salt stress in plants. Curr Opin Cell Biol 13(4):399-404
5)	Pascual-Ahuir A, et al. (2001) Multiple levels of control regulate the yeast cAMP-response element-binding protein repressor Sko1p in response to stress. J Biol Chem 276(40):37373-8
6)	Proft M and Struhl K (2002) Hog1 kinase converts the Sko1-Cyc8-Tup1 repressor complex into an activator that recruits SAGA and SWI/SNF in response to osmotic stress. Mol Cell 9(6):1307-17
7)	Tomas-Cobos L, et al. (2004) Expression of the HXT1 low affinity glucose transporter requires the coordinated activities of the HOG and glucose signalling pathways. J Biol Chem 279(21):22010-9
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41