LSM7/YNL147W Protein Information Help

Standard Name Lsm7p 1
Systematic Name Ynl147wp
ORF Classification Verified
Description Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress (2, 3, 4, 5, 6)
Name Description Like SM 1
Experimental Data
Molecules/cell 3070 7
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 115
Molecular Weight (Da) 13,006
Isoelectric Point (pI) 10.12

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Lsm7p (InterPro)
Physical Interactions There are 133 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000153C028 | P53905
MIPS: YNL147W
NCBI: 1302101 | 150421590 | 158267618 | 1730785 | 854491 | NP_014252.2
GenBank/EMBL/DDBJ: DAA10401.1 | Z46843 | Z71423
Amino Acid Sequence (or in FASTA format)
 
       1  MHQQHSKSEN KPQQQRKKFE GPKREAILDL AKYKDSKIRV KLMGGKLVIG
      51  VLKGYDQLMN LVLDDTVEYM SNPDDENNTE LISKNARKLG LTVIRGTILV
     101  SLSSAEGSDV LYMQK*

external links for Lsm7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Lsm7p
1) Mayes AE, et al.  (1999) Characterization of Sm-like proteins in yeast and their association with U6 snRNA. EMBO J 18(15):4321-31
2) He W and Parker R  (2000) Functions of Lsm proteins in mRNA degradation and splicing. Curr Opin Cell Biol 12(3):346-50
3) Kufel J, et al.  (2004) Nuclear pre-mRNA decapping and 5' degradation in yeast require the Lsm2-8p complex. Mol Cell Biol 24(21):9646-57
4) Beggs JD  (2005) Lsm proteins and RNA processing. Biochem Soc Trans 33(Pt 3):433-8
5) Li Z, et al.  (2009) Rational extension of the ribosome biogenesis pathway using network-guided genetics. PLoS Biol 7(10):e1000213
6) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
7) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41