FPR1/YNL135C Protein Information Help

Standard Name Fpr1p 1
Systematic Name Ynl135cp
Alias Fkb1p , Rbp1p
ORF Classification Verified
Description Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function (1, 2, 3)
Name Description Fk 506-sensitive Proline Rotamase 1
Experimental Data
Molecules/cell 43300 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 114
Molecular Weight (Da) 12,158
Isoelectric Point (pI) 5.87

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Fpr1p (InterPro)
Physical Interactions There are 60 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000005310B | P20081
MIPS: YNL135C
NCBI: 120227 | 1302078 | 157834293 | 171510 | 171519 | 172369 | 45269884 | 6324194 | 854502 | NP_014264.1
GenBank/EMBL/DDBJ: DAA10413.1 | AY557997 | M57967 | M60877 | M63892 | Z46843 | Z71411
External Classifications EC: 5.2.1.8 [Peptidylprolyl isomerase]
Amino Acid Sequence (or in FASTA format)
 
       1  MSEVIEGNVK IDRISPGDGA TFPKTGDLVT IHYTGTLENG QKFDSSVDRG
      51  SPFQCNIGVG QVIKGWDVGI PKLSVGEKAR LTIPGPYAYG PRGFPGLIPP
     101  NSTLVFDVEL LKVN*

external links for Fpr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Fpr1p
1) Heitman J, et al.  (1991) FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 88(5):1948-52
2) Koltin Y, et al.  (1991) Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein. Mol Cell Biol 11(3):1718-23
3) Dolinski KJ and Heitman J  (1999) Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase. Genetics 151(3):935-44
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41