YNL134C Protein Information

Systematic Name	Ynl134cp
ORF Classification	Verified
Description	Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)

Experimental Data
Molecules/cell	3490 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	376
Molecular Weight (Da)	41,164
Isoelectric Point (pI)	6.14

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ynl134cp (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000004F05A \| P53912 MIPS: YNL134C NCBI: 1302076 \| 1730779 \| 398364703 \| 45269934 \| 854503 \| NP_014265.3 GenBank/EMBL/DDBJ: DAA10414.1 \| AY558022 \| Z46843 \| Z71410

Amino Acid Sequence (or in FASTA format)
1 MSASIPETMK AVVIENGKAV VKQDIPIPEL EEGFVLIKTV AVAGNPTDWK 51 HIDFKIGPQG ALLGCDAAGQ IVKLGPNVDA ARFAIGDYIY GVIHGASVRF 101 PSNGAFAEYS AISSETAYKP AREFRLCGKD KLPEGPVKSL EGAVSLPVSL 151 TTAGMILTHS FGLDMTWKPS KAQRDQPILF WGGATAVGQM LIQLAKKLNG 201 FSKIIVVASR KHEKLLKEYG ADELFDYHDA DVIEQIKKKY NNIPYLVDCV 251 SNTETIQQVY KCAADDLDAT VVQLTVLTEK DIKEEDRRQN VSIEGTLLYL 301 IGGNDVPFGT FTLPADPEYK EAAIKFIKFI NPKINDGEIH HIPVKVYKNG 351 LDDIPQLLDD IKHGRNSGEK LVAVLK*

Amino Acid Sequence (or in FASTA format)

       1  MSASIPETMK AVVIENGKAV VKQDIPIPEL EEGFVLIKTV AVAGNPTDWK
      51  HIDFKIGPQG ALLGCDAAGQ IVKLGPNVDA ARFAIGDYIY GVIHGASVRF
     101  PSNGAFAEYS AISSETAYKP AREFRLCGKD KLPEGPVKSL EGAVSLPVSL
     151  TTAGMILTHS FGLDMTWKPS KAQRDQPILF WGGATAVGQM LIQLAKKLNG
     201  FSKIIVVASR KHEKLLKEYG ADELFDYHDA DVIEQIKKKY NNIPYLVDCV
     251  SNTETIQQVY KCAADDLDAT VVQLTVLTEK DIKEEDRRQN VSIEGTLLYL
     301  IGGNDVPFGT FTLPADPEYK EAAIKFIKFI NPKINDGEIH HIPVKVYKNG
     351  LDDIPQLLDD IKHGRNSGEK LVAVLK*

external links for Ynl134cp

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ynl134cp

1)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
2)	Balakrishnan R, et al. (2005) Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Nucleic Acids Res 33 Database Issue:D374-7
3)	Lee MW, et al. (2007) Global protein expression profiling of budding yeast in response to DNA damage. Yeast 24(3):145-54
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41