NRK1/YNL129W Protein Information

Standard Name	Nrk1p 1
Systematic Name	Ynl129wp
ORF Classification	Verified
Description	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis (1, 2)
Name Description	Nicotinamide Riboside Kinase 1

Experimental Data
Molecules/cell	1460 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	240
Molecular Weight (Da)	27,689
Isoelectric Point (pI)	6.68

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Nrk1p (InterPro)
Physical Interactions	There are 1 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BB7C \| P53915 MIPS: YNL129W NCBI: 1302066 \| 1730776 \| 45269912 \| 47156065 \| 6324200 \| 854508 \| NP_014270.1 GenBank/EMBL/DDBJ: DAA10420.1 \| AY558011 \| AY611479 \| Z46843 \| Z71405
External Classifications	EC: 2.7.1.173 [Nicotinate riboside kinase] EC: 2.7.1.22 [Ribosylnicotinamide kinase]

Amino Acid Sequence (or in FASTA format)
1 MTSKKVILVA LSGCSSSGKT TIAKLTASLF TKATLIHEDD FYKHDNEVPV 51 DAKYNIQNWD SPEALDFKLF GKELDVIKQT GKIATKLIHN NNVDDPFTKF 101 HIDRQVWDEL KAKYDSINDD KYEVVIVDGF MIFNNTGISK KFDLKILVRA 151 PYEVLKKRRA SRKGYQTLDS FWVDPPYYFD EFVYESYRAN HAQLFVNGDV 201 EGLLDPRKSK NIKEFINDDD TPIAKPLSWV CQEILKLCKD *

Amino Acid Sequence (or in FASTA format)

       1  MTSKKVILVA LSGCSSSGKT TIAKLTASLF TKATLIHEDD FYKHDNEVPV
      51  DAKYNIQNWD SPEALDFKLF GKELDVIKQT GKIATKLIHN NNVDDPFTKF
     101  HIDRQVWDEL KAKYDSINDD KYEVVIVDGF MIFNNTGISK KFDLKILVRA
     151  PYEVLKKRRA SRKGYQTLDS FWVDPPYYFD EFVYESYRAN HAQLFVNGDV
     201  EGLLDPRKSK NIKEFINDDD TPIAKPLSWV CQEILKLCKD *

external links for Nrk1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Candida (CGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Nrk1p

1)	Bieganowski P and Brenner C (2004) Discoveries of nicotinamide riboside as a nutrient and conserved NRK genes establish a Preiss-Handler independent route to NAD+ in fungi and humans. Cell 117(4):495-502
2)	Tempel W, et al. (2007) Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD(+). PLoS Biol 5(10):e263
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41