MLS1/YNL117W Protein Information

Standard Name	Mls1p 1
Systematic Name	Ynl117wp
ORF Classification	Verified
Description	Malate synthase, enzyme of the glyoxylate cycle; involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth on oleic acid, otherwise cytosolic (1, 2)
Name Description	MaLate Synthase 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	554
Molecular Weight (Da)	62,791
Isoelectric Point (pI)	7.18

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Mls1p (InterPro)
Physical Interactions	There are 22 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012EBE4 \| P30952 MIPS: YNL117W NCBI: 1183956 \| 125863488 \| 125863498 \| 125863508 \| 125863518 \| 125863527 \| 125863540 \| 125863551 \| 125863561 \| 125863571 \| 125863581 \| 125863591 \| 125863611 \| 1302043 \| 3965 \| 400226 \| 62947348 \| 62947350 \| 62947352 \| 62947354 \| 62947356 \| 62947358 \| 62947360 \| 62947362 \| 62947364 \| 62947366 \| 62947368 \| 62947370 \| 62947372 \| 62947374 \| 62947376 \| 62947378 \| 62947380 \| 62947382 \| 62947384 \| 62947386 \| 62947388 \| 62947390 \| 62947392 \| 62947394 \| 62947396 \| 62947398 \| 62947400 \| 62947402 \| 62947404 \| 62947406 \| 62947408 \| 62947410 \| 62947412 \| 62947414 \| 62947416 \| 62947418 \| 62947420 \| 62947422 \| 62947424 \| 62947426 \| 62947428 \| 62947430 \| 62947432 \| 62947434 \| 62947436 \| 62947438 \| 62947440 \| 62947442 \| 62947444 \| 62947446 \| 62947448 \| 62947450 \| 62947452 \| 62947454 \| 62947456 \| 62947458 \| 62947460 \| 62947462 \| 62947464 \| 62947466 \| 62947468 \| 62947470 \| 62947472 \| 62947474 \| 62947476 \| 62947478 \| 62947480 \| 62947482 \| 62947484 \| 62947486 \| 62947488 \| 62947490 \| 62947492 \| 62947494 \| 62947496 \| 62947498 \| 62947500 \| 6324212 \| NP_014282.1 GenBank/EMBL/DDBJ: DAA10431.1 \| AY942279 \| AY942280 \| AY942281 \| AY942282 \| AY942283 \| AY942284 \| AY942285 \| AY942286 \| AY942287 \| AY942288 \| AY942289 \| AY942290 \| AY942291 \| AY942292 \| AY942293 \| AY942294 \| AY942295 \| AY942296 \| AY942297 \| AY942298 \| AY942299 \| AY942300 \| AY942301 \| AY942302 \| AY942303 \| AY942304 \| AY942305 \| AY942306 \| AY942307 \| AY942308 \| AY942309 \| AY942310 \| AY942311 \| AY942312 \| AY942313 \| AY942314 \| AY942315 \| AY942316 \| AY942317 \| AY942318 \| AY942319 \| AY942320 \| AY942321 \| AY942322 \| AY942323 \| AY942324 \| AY942325 \| AY942326 \| AY942327 \| AY942328 \| AY942329 \| AY942330 \| AY942331 \| AY942332 \| AY942333 \| AY942334 \| AY942335 \| AY942336 \| AY942337 \| AY942338 \| AY942339 \| AY942340 \| AY942341 \| AY942342 \| AY942343 \| AY942344 \| AY942345 \| AY942346 \| AY942347 \| AY942348 \| AY942349 \| AY942350 \| AY942351 \| AY942352 \| AY942353 \| AY942354 \| AY942355 \| EF125216 \| EF125217 \| EF125218 \| EF125219 \| EF125220 \| EF125221 \| EF125222 \| EF125223 \| EF125224 \| EF125225 \| EF125226 \| EF125228 \| X64407 \| Z69382 \| Z71393
External Classifications	EC: 2.3.3.9 [Malate synthase]

Amino Acid Sequence (or in FASTA format)
1 MVKVSLDNVK LLVDVDKEPF FKPSSTTVGD ILTKDALEFI VLLHRTFNNK 51 RKQLLENRQV VQKKLDSGSY HLDFLPETAN IRNDPTWQGP ILAPGLINRS 101 TEITGPPLRN MLINALNAPV NTYMTDFEDS ASPTWNNMVY GQVNLYDAIR 151 NQIDFDTPRK SYKLNGNVAN LPTIIVRPRG WHMVEKHLYV DDEPISASIF 201 DFGLYFYHNA KELIKLGKGP YFYLPKMEHH LEAKLWNDVF CVAQDYIGIP 251 RGTIRATVLI ETLPAAFQME EIIYQLRQHS SGLNCGRWDY IFSTIKRLRN 301 DPNHILPNRN QVTMTSPFMD AYVKRLINTC HRRGVHAMGG MAAQIPIKDD 351 PAANEKAMTK VRNDKIRELT NGHDGSWVAH PALAPICNEV FINMGTPNQI 401 YFIPENVVTA ANLLETKIPN GEITTEGIVQ NLDIGLQYME AWLRGSGCVP 451 INNLMEDAAT AEVSRCQLYQ WVKHGVTLKD TGEKVTPELT EKILKEQVER 501 LSKASPLGDK NKFALAAKYF LPEIRGEKFS EFLTTLLYDE IVSTKATPTD 551 LSKL*

Amino Acid Sequence (or in FASTA format)

       1  MVKVSLDNVK LLVDVDKEPF FKPSSTTVGD ILTKDALEFI VLLHRTFNNK
      51  RKQLLENRQV VQKKLDSGSY HLDFLPETAN IRNDPTWQGP ILAPGLINRS
     101  TEITGPPLRN MLINALNAPV NTYMTDFEDS ASPTWNNMVY GQVNLYDAIR
     151  NQIDFDTPRK SYKLNGNVAN LPTIIVRPRG WHMVEKHLYV DDEPISASIF
     201  DFGLYFYHNA KELIKLGKGP YFYLPKMEHH LEAKLWNDVF CVAQDYIGIP
     251  RGTIRATVLI ETLPAAFQME EIIYQLRQHS SGLNCGRWDY IFSTIKRLRN
     301  DPNHILPNRN QVTMTSPFMD AYVKRLINTC HRRGVHAMGG MAAQIPIKDD
     351  PAANEKAMTK VRNDKIRELT NGHDGSWVAH PALAPICNEV FINMGTPNQI
     401  YFIPENVVTA ANLLETKIPN GEITTEGIVQ NLDIGLQYME AWLRGSGCVP
     451  INNLMEDAAT AEVSRCQLYQ WVKHGVTLKD TGEKVTPELT EKILKEQVER
     501  LSKASPLGDK NKFALAAKYF LPEIRGEKFS EFLTTLLYDE IVSTKATPTD
     551  LSKL*

external links for Mls1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Mls1p

1)	Hartig A, et al. (1992) Differentially regulated malate synthase genes participate in carbon and nitrogen metabolism of S. cerevisiae. Nucleic Acids Res 20(21):5677-86
2)	Kunze M, et al. (2002) Targeting of malate synthase 1 to the peroxisomes of Saccharomyces cerevisiae cells depends on growth on oleic acid medium. Eur J Biochem 269(3):915-22