AIM37/YNL100W Protein Information

Standard Name	Aim37p 1
Systematic Name	Ynl100wp
Alias	Mcs27p 2
ORF Classification	Verified
Description	Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of crista junctions and inner membrane architecture (2, 3, 4)
Name Description	Altered Inheritance rate of Mitochondria 1

Experimental Data
Molecules/cell	5460 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	234
Molecular Weight (Da)	26,960
Isoelectric Point (pI)	10.18

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aim37p (InterPro)
Physical Interactions	There are 29 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BB6C \| P50945 MIPS: YNL100W NCBI: 1302012 \| 1730757 \| 51012859 \| 6324229 \| 71064099 \| 929853 \| NP_014299.1 GenBank/EMBL/DDBJ: DAA10445.1 \| AY692704 \| DQ115393 \| Z50161 \| Z71376

Amino Acid Sequence (or in FASTA format)
1 MVNFYDDVDE SKSHGEFPLI PVVLQNSSEL SVRTIPTGNE IIESVHLTKW 51 LRKYRNALAS QLDRYEKGWQ SKIANFRLQV QHVINYSRKN IFNVDSENKH 101 TVVPGSLIAL GAFFAGSIAV NRSNWGAKRL IFGHKSSILE KLCTSLPSRI 151 LLPWVLAAAT FKYWAPQTSQ NLVNATENDL LPADFVKSYH NTWKRIYEEG 201 YVAKKCDLKR QIDQTLQKNI RYAREQLYEK LEQA*

Amino Acid Sequence (or in FASTA format)

       1  MVNFYDDVDE SKSHGEFPLI PVVLQNSSEL SVRTIPTGNE IIESVHLTKW
      51  LRKYRNALAS QLDRYEKGWQ SKIANFRLQV QHVINYSRKN IFNVDSENKH
     101  TVVPGSLIAL GAFFAGSIAV NRSNWGAKRL IFGHKSSILE KLCTSLPSRI
     151  LLPWVLAAAT FKYWAPQTSQ NLVNATENDL LPADFVKSYH NTWKRIYEEG
     201  YVAKKCDLKR QIDQTLQKNI RYAREQLYEK LEQA*

external links for Aim37p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome
	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Aim37p

1)	Hess DC, et al. (2009) Computationally driven, quantitative experiments discover genes required for mitochondrial biogenesis. PLoS Genet 5(3):e1000407
2)	Harner M, et al. (2011) The mitochondrial contact site complex, a determinant of mitochondrial architecture.LID - 10.1038/emboj.2011.379 [doi] EMBO J ()
3)	von der Malsburg K, et al. (2011) Dual role of mitofilin in mitochondrial membrane organization and protein biogenesis. Dev Cell 21(4):694-707
4)	Hoppins S, et al. (2011) A mitochondrial-focused genetic interaction map reveals a scaffold-like complex required for inner membrane organization in mitochondria. J Cell Biol 195(2):323-40
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41