RAS2/YNL098C Protein Information

Standard Name	Ras2p 1
Systematic Name	Ynl098cp
Alias	Ctn5p , Cyr3p , Glc5p , Tsl7p
ORF Classification	Verified
Description	GTP-binding protein; regulates nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes; RAS2 has a paralog, RAS1, that arose from the whole genome duplication (2, 3, 4, 5)
Name Description	homologous to RAS proto-oncogene

Experimental Data
Molecules/cell	19800 6

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	322
Molecular Weight (Da)	34,705
Isoelectric Point (pI)	7.35

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ras2p (InterPro)
Physical Interactions	There are 43 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00001683F6 \| P01120 MIPS: YNL098C NCBI: 1302008 \| 1710014 \| 172363 \| 2447015 \| 4291 \| 6324231 \| 71064101 \| 929855 \| NP_014301.1 GenBank/EMBL/DDBJ: DAA10447.1 \| D37950 \| DQ115393 \| K01971 \| X00528 \| Z50161 \| Z71374

Amino Acid Sequence (or in FASTA format)
1 MPLNKSNIRE YKLVVVGGGG VGKSALTIQL TQSHFVDEYD PTIEDSYRKQ 51 VVIDDEVSIL DILDTAGQEE YSAMREQYMR NGEGFLLVYS ITSKSSLDEL 101 MTYYQQILRV KDTDYVPIVV VGNKSDLENE KQVSYQDGLN MAKQMNAPFL 151 ETSAKQAINV EEAFYTLARL VRDEGGKYNK TLTENDNSKQ TSQDTKGSGA 201 NSVPRNSGGH RKMSNAANGK NVNSSTTVVN ARNASIESKT GLAGNQATNG 251 KTQTDRTNID NSTGQAGQAN AQSANTVNNR VNNNSKAGQV SNAKQARKQQ 301 AAPGGNTSEA SKSGSGGCCI IS*

Amino Acid Sequence (or in FASTA format)

       1  MPLNKSNIRE YKLVVVGGGG VGKSALTIQL TQSHFVDEYD PTIEDSYRKQ
      51  VVIDDEVSIL DILDTAGQEE YSAMREQYMR NGEGFLLVYS ITSKSSLDEL
     101  MTYYQQILRV KDTDYVPIVV VGNKSDLENE KQVSYQDGLN MAKQMNAPFL
     151  ETSAKQAINV EEAFYTLARL VRDEGGKYNK TLTENDNSKQ TSQDTKGSGA
     201  NSVPRNSGGH RKMSNAANGK NVNSSTTVVN ARNASIESKT GLAGNQATNG
     251  KTQTDRTNID NSTGQAGQAN AQSANTVNNR VNNNSKAGQV SNAKQARKQQ
     301  AAPGGNTSEA SKSGSGGCCI IS*

external links for Ras2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Ras2p

1)	Robinson, L. and Tatchell, K. (1985) Personal Communication, Mortimer Map Edition 9
2)	Gimeno CJ, et al. (1992) Unipolar cell divisions in the yeast S. cerevisiae lead to filamentous growth: regulation by starvation and RAS. Cell 68(6):1077-90
3)	Kataoka T, et al. (1984) Genetic analysis of yeast RAS1 and RAS2 genes. Cell 37(2):437-45
4)	Bhattacharya S, et al. (1995) Ras membrane targeting is essential for glucose signaling but not for viability in yeast. Proc Natl Acad Sci U S A 92(7):2984-8
5)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
6)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41