IMP4/YNL075W Protein Information

Standard Name	Imp4p
Systematic Name	Ynl075wp
ORF Classification	Verified
Description	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs (1, 2, 3)
Name Description	Interacting with Mpp10p 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	290
Molecular Weight (Da)	33,482
Isoelectric Point (pI)	9.79

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Imp4p (InterPro)
Physical Interactions	There are 69 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000036C8A \| P53941 MIPS: YNL075W NCBI: 1301963 \| 1730744 \| 398365039 \| 791110 \| NP_014324.3 GenBank/EMBL/DDBJ: DAA10470.1 \| X86470 \| Z71351

Amino Acid Sequence (or in FASTA format)
1 MLRRQARERR EYLYRKAQEL QDSQLQQKRQ IIKQALAQGK PLPKELAEDE 51 SLQKDFRYDQ SLKESEEADD LQVDDEYAAT SGIMDPRIIV TTSRDPSTRL 101 SQFAKEIKLL FPNAVRLNRG NYVMPNLVDA CKKSGTTDLV VLHEHRGVPT 151 SLTISHFPHG PTAQFSLHNV VMRHDIINAG NQSEVNPHLI FDNFTTALGK 201 RVVCILKHLF NAGPKKDSER VITFANRGDF ISVRQHVYVR TREGVEIAEV 251 GPRFEMRLFE LRLGTLENKD ADVEWQLRRF IRTANKKDYL *

Amino Acid Sequence (or in FASTA format)

       1  MLRRQARERR EYLYRKAQEL QDSQLQQKRQ IIKQALAQGK PLPKELAEDE
      51  SLQKDFRYDQ SLKESEEADD LQVDDEYAAT SGIMDPRIIV TTSRDPSTRL
     101  SQFAKEIKLL FPNAVRLNRG NYVMPNLVDA CKKSGTTDLV VLHEHRGVPT
     151  SLTISHFPHG PTAQFSLHNV VMRHDIINAG NQSEVNPHLI FDNFTTALGK
     201  RVVCILKHLF NAGPKKDSER VITFANRGDF ISVRQHVYVR TREGVEIAEV
     251  GPRFEMRLFE LRLGTLENKD ADVEWQLRRF IRTANKKDYL *

external links for Imp4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome	YeastRC Structure Prediction (Seattle)
YOGY	DIP
	GeneMANIA
	YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Imp4p

1)	Lee SJ and Baserga SJ (1999) Imp3p and Imp4p, two specific components of the U3 small nucleolar ribonucleoprotein that are essential for pre-18S rRNA processing. Mol Cell Biol 19(8):5441-52
2)	Wehner KA and Baserga SJ (2002) The sigma(70)-like motif: a eukaryotic RNA binding domain unique to a superfamily of proteins required for ribosome biogenesis. Mol Cell 9(2):329-39
3)	Wehner KA, et al. (2002) Components of an interdependent unit within the SSU processome regulate and mediate its activity. Mol Cell Biol 22(20):7258-67