AQR1/YNL065W Protein Information Help

Standard Name Aqr1p 1
Systematic Name Ynl065wp
ORF Classification Verified
Description Plasma membrane transporter of the major facilitator superfamily; member of the 12-spanner drug:H(+) antiporter DHA1 family; confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids; AQR1 has a paralog, QDR1, that arose from the whole genome duplication; relocalizes from plasma membrane to cytoplasm upon DNA replication stress (1, 2, 3, 4, 5)
Name Description Acids Quinidine Resistance 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 586
Molecular Weight (Da) 65,296
Isoelectric Point (pI) 9

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Aqr1p (InterPro)
Transmembrane Domains There are 10 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013BB3A | P53943
MIPS: YNL065W
NCBI: 1301943 | 1730741 | 398365123 | 51013695 | 791123 | 994822 | NP_014334.3
GenBank/EMBL/DDBJ: DAA10481.1 | AY693122 | U12141 | X86470 | Z71341
External Classifications TC: 2.A.1.2 [The Drug:H+ Antiporter-1 (12 Spanner) (DHA1) Family]
Amino Acid Sequence (or in FASTA format)
 
       1  MSRSNSIYTE DIEMYPTHNE QHLTREYTKP DGQTKSEKLN FEGAYINSHG
      51  TLSKTTTREI EGDLDSETSS HSSDDKVDPT QQITAETKAP YTLLSYGQKW
     101  GMVAILTMCG FWSSLGSPIY YPALRQLEKQ FNVDENMVNV TVVVYLLFQG
     151  ISPTVSGGLA DCFGRRPIIL AGMLIYVIAS IGLACAPSYG VIIFLRCIQS
     201  IGISPTIAIS SGVVGDFTLK HERGTFVGAT SGFVLLGQCF GSLIGAVLTA
     251  RWDWRAIFWF LTIGCGSCFL IAFLILPETK RTIAGNLSIK PKRFINRAPI
     301  FLLGPVRRRF KYDNPDYETL DPTIPKLDLS SAGKILVLPE IILSLFPSGL
     351  LFAMWTLMLS SISSGLSVAP YNYHLVIIGV CYLPGGIGGL MGSFFTGRII
     401  DMYFKRKIKK FEQDKANGLI PQDAEINMFK VRLVCLLPQN FLAVVAYLLF
     451  GWSIDKGWRI ESILITSFVC SYCAMSTLST STTLLVDLYP TKSSTASSCF
     501  NFVRCSLSTI FMGCFAKMKA AMTVGGTFTF LCALVFFFNF LMFIPMKYGM
     551  KWREDRLLKQ QRQSWLNTLA VKAKKGTKRD QNDNHN*

external links for Aqr1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome TCDB

GeneMANIA YeastRC Structure Prediction (Seattle)

References cited on this page View Complete Literature Guide for Aqr1p
1) Tenreiro S, et al.  (2002) AQR1 gene (ORF YNL065w) encodes a plasma membrane transporter of the major facilitator superfamily that confers resistance to short-chain monocarboxylic acids and quinidine in Saccharomyces cerevisiae. Biochem Biophys Res Commun 292(3):741-8
2) Velasco I, et al.  (2004) Saccharomyces cerevisiae Aqr1 is an internal-membrane transporter involved in excretion of amino acids. Eukaryot Cell 3(6):1492-503
3) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4) Dias PJ, et al.  (2010) Evolution of the 12-Spanner Drug:H+ Antiporter DHA1 Family in Hemiascomycetous Yeasts. OMICS 14(6):701-10
5) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76