VAC7/YNL054W Protein Information Help

Standard Name Vac7p 1
Systematic Name Ynl054wp
ORF Classification Verified
Description Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock (1, 2, 3)
Name Description VACuolar segregation
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,165
Molecular Weight (Da) 128,139
Isoelectric Point (pI) 5.87

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Vac7p (InterPro)
Transmembrane Domains There are 1 total predicted transmembrane domains (TMHMM)
Physical Interactions There are 10 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000036C88 | P53950
MIPS: YNL054W
NCBI: 1098487 | 1301921 | 1730734 | 398365209 | NP_014344.3
GenBank/EMBL/DDBJ: DAA10491.1 | U12141 | Z71330
Amino Acid Sequence (or in FASTA format)
 
       1  MTEEDRKLTV ETETVEAPVA NNLLLSNNSN VVAPNPSIPS ASTSTSPLHR
      51  EIVDDSVATA NTTSNVVQHN LPTIDNNLMD SDATSHNQDH WHSDINRAGT
     101  SMSTSDIPTD LHLEHIGSVS STNNNSNNAL INHNPLSSHL SNPSSSLRNK
     151  KSSLLVASNP AFASDVELSK KKPAVISNNM PTSNIALYQT ARSANIHGPS
     201  STSASKAFRK ASAFSNNTAP STSNNIGSNT PPAPLLPLPS LSQQNKPKII
     251  ERPTMHVTNS REILLGENLL DDTKAKNAPA NSTTHDNGPV ANDGLRIPNH
     301  SNADDNENNN KMKKNKNINS GKNERNDDTS KICTTSTKTA PSTAPLGSTD
     351  NTQALTASVS SSNADNHNNN KKKTSSNNNG NNSNSASNKT NADIKNSNAD
     401  LSASTSNNNA INDDSHESNS EKPTKADFFA ARLATAVGEN EISDSEETFV
     451  YESAANSTKN LIFPDSSSQQ QQQQQQPPKQ QQQQQNHGIT SKISAPLLNN
     501  NKKLLSRLKN SRHISTGAIL NNTIATISTN PNLNSNVMQN NNNLMSGHNH
     551  LDELSSIKQE PPHQLQQQQP PMDVQSVDSY TSDNPDSNVI AKSPDKRSSL
     601  VSLSKVSPHL LSSTSSNGNT ISCPNVATNS QELEPNNDIS TKKSLSNSTL
     651  RHSSANRNSN YGDNKRPLRT TVSKIFDSNP NGAPLRRYSG VPDHVNLEDY
     701  IEQPHNYPTM QNSVKKDEFY NSRNNKFPHG LNFYGDNNVI EEENNGDSSN
     751  VNRPQHTNLQ HEFIPEDNES DENDIHSMFY YNHKNDLETK PLISDYGEDE
     801  DVDDYDRPNA TFNSYYGSAS NTHELPLHGR MPSRSNNDYY DFMVGNNTGN
     851  NNQLNEYTPL RMKRGQRHLS RTNNSIMNGS IHMNGNDDVT HSNINNNDIV
     901  GYSPHNFYSR KSPFVKVKNF LYLAFVISSL LMTGFILGFL LATNKELQDV
     951  DVVVMDNVIS SSDELIFDIT VSAFNPGFFS ISVSQVDLDI FAKSSYLKCD
    1001  SNGDCTVMEQ ERKILQITTN LSLVEESANN DISGGNIETV LLGTAKKLET
    1051  PLKFQGGAFN RNYDVSVSSV KLLSPGSREA KHENDDDDDD DGDDGDDENN
    1101  TNERQYKSKP NARDDKEDDT KKWKLLIKHD YELIVRGSMK YEVPFFNTQK
    1151  STAIQKDSMV HPGKK*

external links for Vac7p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Vac7p
1) Bonangelino CJ, et al.  (1997) Vac7p, a novel vacuolar protein, is required for normal vacuole inheritance and morphology. Mol Cell Biol 17(12):6847-58
2) Gary JD, et al.  (2002) Regulation of Fab1 phosphatidylinositol 3-phosphate 5-kinase pathway by Vac7 protein and Fig4, a polyphosphoinositide phosphatase family member. Mol Biol Cell 13(4):1238-51
3) Duex JE, et al.  (2006) The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnover. J Cell Biol 172(5):693-704