SFB2/YNL049C Protein Information Help

Standard Name Sfb2p 1
Systematic Name Ynl049cp
Alias Iss1p 2
ORF Classification Verified
Description Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat; required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb3p; SFB2 has a paralog, SEC24, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Sed Five Binding 1
Experimental Data
Molecules/cell 1720 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 876
Molecular Weight (Da) 98,942
Isoelectric Point (pI) 5.04

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Sfb2p (InterPro)
Physical Interactions There are 24 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001358AC | P53953
MIPS: YNL049C
NCBI: 1098489 | 1149539 | 1301909 | 1730731 | 2253169 | 3355837 | 51013107 | 6324279 | NP_014349.1
GenBank/EMBL/DDBJ: DAA10496.1 | AJ009783 | AY692828 | U12141 | X94547 | Z71324 | Z71325
Amino Acid Sequence (or in FASTA format)
 
       1  MSHHKKRVYP QAQVPYIASM PIVAEQQQSQ QQIDQTAYAM GNLQLNNRAN
      51  SFTQLAQNQQ FPGSGKVVNQ LYPVDLFTEL PPPIRDLSLP PLPITISQDN
     101  IVTPSEYSNV PYQYVRSTLK AVPKTNSLLK KTKLPFAIVI RPYLHLQDSD
     151  NQVPLNTDGV IVRCRRCRSY MNPFVVFINQ GRKWQCNICR FKNDVPFGFD
     201  QNLQGAPINR YERNEIKNSV VDYLAPVEYS VREPPPSVYV FLLDVSQNAV
     251  KNGLLATSAR TILENIEFLP NHDGRTRIAI ICVDHSLHYF YVPLDDDYEV
     301  SDEDDEESDG EEEDEDEEEE DVDNSETIQM FDIGDLDEPF LPMPSDELVV
     351  PLKYCKNNLE TLLKKIPEIF QDTHSSKFAL GPALKAASNL IKSTGGKVEV
     401  ISSTLPNTGI GKLKKRSEQG ILNTPKESSQ LLSCKDSFYK TFTIECNKLQ
     451  ITVDMFLASE DYMDVATLSH LGRFSGGQTH FYPGFNATSL NDVTKFTREL
     501  SRHLSMDISM EAVMRVRCST GLRATSFFGH FFNRSSDLCA FSTMPRDQSY
     551  LFGISIEDSL MAEYCYLQVS TLLTLNTGER RIRVMTLALP TSESAREVFA
     601  SADQLAITDF MTQNAVTKAL NSSMYSARDF ITKSLEDILN AYKKEISMSN
     651  INSVTSLNLC ANLRMLPLLM NGLSKHIALR PGVVPSDYRA SALNRLETEP
     701  LHYLIKSIYP TVYSLHDMPD EVGLPDFEGK TVLPEPINAT ISLFERYGLY
     751  LIDNSAELFL WVGGDAVPEL LIDVFNTDTI SQIPVGKSEL PLLNDSPFNE
     801  RLRRIIGRIR ENNDTITFQS LYIIRGPSIN EPANLNSEKD MASLRLWVLS
     851  TLVEDKVLNC ASYREYLQSM KTSINR*

external links for Sfb2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Sfb2p
1) Peng R, et al.  (2000) Evidence for overlapping and distinct functions in protein transport of coat protein Sec24p family members. J Biol Chem 275(15):11521-8
2) Kurihara T, et al.  (2000) Sec24p and Iss1p function interchangeably in transport vesicle formation from the endoplasmic reticulum in Saccharomyces cerevisiae. Mol Biol Cell 11(3):983-98
3) Miller EA, et al.  (2003) Multiple cargo binding sites on the COPII subunit Sec24p ensure capture of diverse membrane proteins into transport vesicles. Cell 114(4):497-509
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41