YNL035C Protein Information

Systematic Name	Ynl035cp
ORF Classification	Verified
Description	Protein of unknown function; contains WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)

Experimental Data
Molecules/cell	3970 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	389
Molecular Weight (Da)	43,848
Isoelectric Point (pI)	5.17

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ynl035cp (InterPro)
Physical Interactions	There are 5 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013BB06 \| P53962 MIPS: YNL035C NCBI: 1301880 \| 1730722 \| 6324293 \| NP_014363.1 GenBank/EMBL/DDBJ: DAA10510.1 \| Z71311

Amino Acid Sequence (or in FASTA format)
1 MASYSLVESN SFGSENWCLK LQPSYKHGLL TGLSNGEIRL LDWSTGKSVQ 51 KIKASETAIN DMKVIGSDFS AGHLVSSASI DAVKVFDIRT NDRIAQIQNE 101 ANSPFISLDS RHGLLACGTE LQGIDAAVYI YDIRKWDTPL RSLIDSHHDD 151 VTCIKFHPSD VNILLSGSTD GYTNIYDLKQ DEEEDALHQV INYASIHSCG 201 WLSPKRIFTL SHMETFAIHE LNDKSDELKE PQPLDFGDVR EIWNCDYVVD 251 IYPGLIATGK TQENCGELCL LPFKDEKVDT ENGIVIPHAH GDEVVRDIFI 301 PAQHSNMLYS CGEDGCVKIW ENKQGPLDIP ENFWDYSKKM NVLGDDDREG 351 SINLDEPLII QKESVSTRPR KEKHKKAKKH SMKSRFKPY*

Amino Acid Sequence (or in FASTA format)

       1  MASYSLVESN SFGSENWCLK LQPSYKHGLL TGLSNGEIRL LDWSTGKSVQ
      51  KIKASETAIN DMKVIGSDFS AGHLVSSASI DAVKVFDIRT NDRIAQIQNE
     101  ANSPFISLDS RHGLLACGTE LQGIDAAVYI YDIRKWDTPL RSLIDSHHDD
     151  VTCIKFHPSD VNILLSGSTD GYTNIYDLKQ DEEEDALHQV INYASIHSCG
     201  WLSPKRIFTL SHMETFAIHE LNDKSDELKE PQPLDFGDVR EIWNCDYVVD
     251  IYPGLIATGK TQENCGELCL LPFKDEKVDT ENGIVIPHAH GDEVVRDIFI
     301  PAQHSNMLYS CGEDGCVKIW ENKQGPLDIP ENFWDYSKKM NVLGDDDREG
     351  SINLDEPLII QKESVSTRPR KEKHKKAKKH SMKSRFKPY*

external links for Ynl035cp

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ynl035cp

1)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Balakrishnan R, et al. (2005) Fungal BLAST and Model Organism BLASTP Best Hits: new comparison resources at the Saccharomyces Genome Database (SGD). Nucleic Acids Res 33 Database Issue:D374-7
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41