HHT2/YNL031C Protein Information Help

Standard Name Hht2p
Systematic Name Ynl031cp
ORF Classification Verified
Description Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation (1, 2, 3, 4, 5, 6, 7, 8)
Name Description Histone H Three
Experimental Data
Molecules/cell 248000 9
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 136
Molecular Weight (Da) 15,356
Isoelectric Point (pI) 12

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hht2p (InterPro)
Physical Interactions There are 807 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000009B9 | P61830
MIPS: YNL031C
NCBI: 119389629 | 126030725 | 1301870 | 151567738 | 15988132 | 15988136 | 187609129 | 187609131 | 2253166 | 24987664 | 24987666 | 321160032 | 3755 | 3758 | 402550037 | 45270576 | 45439479 | 45439481 | 45439483 | 45439485 | 45439487 | 45439489 | 45439491 | 45439493 | 45439495 | 48428921 | 51013425 | 536204 | 6137607 | 6319482 | 6324297 | NP_009564.1 | NP_014367.1
GenBank/EMBL/DDBJ: DAA07131.1 | DAA10514.1 | AY554000 | AY554001 | AY554002 | AY554003 | AY554004 | AY554005 | AY554006 | AY554007 | AY554008 | AY558343 | AY692987 | X00724 | X00725 | Z35879 | Z71306 | Z71307
Amino Acid Sequence (or in FASTA format)
 
       1  MARTKQTARK STGGKAPRKQ LASKAARKSA PSTGGVKKPH RYKPGTVALR
      51  EIRRFQKSTE LLIRKLPFQR LVREIAQDFK TDLRFQSSAI GALQESVEAY
     101  LVSLFEDTNL AAIHAKRVTI QKKDIKLARR LRGERS*

external links for Hht2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CGD) Complexome YeastRC Structure Prediction (Seattle)
Candida (CandidaDB) DIP

Candida (CandidaDB) GeneMANIA

YGOB


YOGY


References cited on this page View Complete Literature Guide for Hht2p
1) Zhang W, et al.  (1998) Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. EMBO J 17(11):3155-67
2) Lo WS, et al.  (2000) Phosphorylation of serine 10 in histone H3 is functionally linked in vitro and in vivo to Gcn5-mediated acetylation at lysine 14. Mol Cell 5(6):917-26
3) Hsu JY, et al.  (2000) Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Cell 102(3):279-91
4) Smith MM and Andresson OS  (1983) DNA sequences of yeast H3 and H4 histone genes from two non-allelic gene sets encode identical H3 and H4 proteins. J Mol Biol 169(3):663-90
5) van Leeuwen F, et al.  (2002) Dot1p modulates silencing in yeast by methylation of the nucleosome core. Cell 109(6):745-56
6) Thompson JS, et al.  (2003) Identification of a Functional Domain Within the Essential Core of Histone H3 That Is Required for Telomeric and HM Silencing in Saccharomyces cerevisiae. Genetics 163(1):447-52
7) Krogan NJ, et al.  (2003) The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation. Mol Cell 11(3):721-9
8) Boa S, et al.  (2003) Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression. Yeast 20(9):827-35
9) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41