CRZ1/YNL027W Protein Information Help

Standard Name Crz1p 1
Systematic Name Ynl027wp
Alias Hal8p 2 , Tcn1p 1, 3
ORF Classification Verified
Description Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress (1, 3, 4, 5)
Name Description Calcineurin-Responsive Zinc finger 1
Experimental Data
Molecules/cell 1160 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 678
Molecular Weight (Da) 76,300
Isoelectric Point (pI) 6.04

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Crz1p (InterPro)
Physical Interactions There are 44 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013BAF4 | P53968
MIPS: YNL027W
NCBI: 1301863 | 1730716 | 6324301 | NP_014371.1
GenBank/EMBL/DDBJ: DAA10517.1 | Z71303
Amino Acid Sequence (or in FASTA format)
 
       1  MSFSNGNMAS YMTSSNGEEQ SINNKNDIDD NSAYRRNNFR NSSNSGSHTF
      51  QLSDLDLDVD MRMDSANSSE KISKNLSSGI PDSFDSNVNS LLSPSSGSYS
     101  ADLNYQSLYK PDLPQQQLQQ QQLQQQQQQQ QQQQQQQQKQ TPTLKVEQSD
     151  TFQWDDILTP ADNQHRPSLT NQFLSPRSNY DGTTRSSGID SNYSDTESNY
     201  HTPYLYPQDL VSSPAMSHLT ANNDDFDDLL SVASMNSNYL LPVNSHGYKH
     251  ISNLDELDDL LSLTYSDNNL LSASNNSDFN NSNNGIINTA DTQNSTIAIN
     301  KSKVGTNQKM LLTIPTSSTP SPSTHAAPVT PIISIQEFNE GHFPVKNEDD
     351  GTLQLKVRDN ESYSATNNNN LLRPDDNDYN NEALSDIDRS FEDIINGRKL
     401  KLKKSRRRSS QTSNNSFTSR RSSRSRSISP DEKAKSISAN REKLLEMADL
     451  LPSSENDNNR ERYDNDSKTS YNTINSSNFN EDNNNNNLLT SKPKIESGIV
     501  NIKNELDDTS KDLGILLDID SLGQFEQKVG FKNDDNHENN DNGTFSVKKN
     551  DNLEKLDSVT NNRKNPANFA CDVCGKKFTR PYNLKSHLRT HTNERPFICS
     601  ICGKAFARQH DRKRHEDLHT GKKRYVCGGK LKDGKPWGCG KKFARSDALG
     651  RHFKTESGRR CITPLYEEAR QEKSGQES*

external links for Crz1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Crz1p
1) Stathopoulos AM and Cyert MS  (1997) Calcineurin acts through the CRZ1/TCN1-encoded transcription factor to regulate gene expression in yeast. Genes Dev 11(24):3432-44
2) Mendizabal I, et al.  (1998) Yeast putative transcription factors involved in salt tolerance. FEBS Lett 425(2):323-8
3) Matheos DP, et al.  (1997) Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae. Genes Dev 11(24):3445-58
4) Boustany LM and Cyert MS  (2002) Calcineurin-dependent regulation of Crz1p nuclear export requires Msn5p and a conserved calcineurin docking site. Genes Dev 16(5):608-19
5) Bodvard K, et al.  (2013) The yeast transcription factor Crz1 is activated by light in a Ca2+/calcineurin-dependent and PKA-independent manner. PLoS One 8(1):e53404
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41