ARK1/YNL020C Protein Information

Standard Name	Ark1p 1
Systematic Name	Ynl020cp
ORF Classification	Verified
Description	Serine/threonine protein kinase; involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis; ARK1 has a paralog, PRK1, that arose from the whole genome duplication (1, 2, 3)
Name Description	Actin Regulating Kinase 1

Experimental Data
Molecules/cell	1550 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	638
Molecular Weight (Da)	71,372
Isoelectric Point (pI)	9.25

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ark1p (InterPro)
Physical Interactions	There are 38 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012DF16 \| P53974 MIPS: YNL020C NCBI: 1301849 \| 1730058 \| 240104241 \| 6324308 \| NP_014378.1 GenBank/EMBL/DDBJ: DAA10525.1 \| Z71296
External Classifications	EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]

Amino Acid Sequence (or in FASTA format)
1 MNQPQIGTYN VGTQLTVGSH QVEIIKYLTS GGFAQVYSAL INPPDPHSNS 51 SVACLKRVIV PDKPSLNTLR AEVDAMRLLK NNRYVVSYID SHAAKAMLHN 101 GSYEVFVLME YCERGGLIDF MNTRLQNRLH EFEILQIMSQ VTQGVAAMHA 151 LQPPLIHRDI KIENVLISAN NEYKLCDFGS VCGIIRPPRN SQELSYVQQD 201 ILKNTTAQYR SPEMIDTFRG LPIDEKSDIW ALGIFLYKLC YYTTPFEKGG 251 DLAILSGKFE FPLYPNYSEQ LKGLIRDILV QDPRHRPNVY QLLKRISIMQ 301 NVPCPINDIQ VVQAPSSHLN LTELHQLSAT QNILSLNSPT TMENTMPNAT 351 FQISMADNTT TAQMHPNRKP SQIAYDASFS NSAKGSQPLF DKSQNMYHAL 401 DPPLVEPLAS SVSNNDNELK ANSATKLKQA IVSEAHTFRQ NNSIDFPLQN 451 IIPQYEDSSS SSDESYSGDV DELKKTRSLG SYSTRGNIKK NQSVKESLTS 501 SSLPGTSFTP TSTKVNLKHE NSPFKSTFVN TIDNSKDDLN KPSYEDLDVS 551 KQNLKNSIQQ RMIDKLNSSE ESFNARKMSK VKLHEKGEID KPTMLKSSGP 601 ISKDKKTKPT PPPKPSHLKP KPPPKPLLLA GRKLSLDK*

Amino Acid Sequence (or in FASTA format)

       1  MNQPQIGTYN VGTQLTVGSH QVEIIKYLTS GGFAQVYSAL INPPDPHSNS
      51  SVACLKRVIV PDKPSLNTLR AEVDAMRLLK NNRYVVSYID SHAAKAMLHN
     101  GSYEVFVLME YCERGGLIDF MNTRLQNRLH EFEILQIMSQ VTQGVAAMHA
     151  LQPPLIHRDI KIENVLISAN NEYKLCDFGS VCGIIRPPRN SQELSYVQQD
     201  ILKNTTAQYR SPEMIDTFRG LPIDEKSDIW ALGIFLYKLC YYTTPFEKGG
     251  DLAILSGKFE FPLYPNYSEQ LKGLIRDILV QDPRHRPNVY QLLKRISIMQ
     301  NVPCPINDIQ VVQAPSSHLN LTELHQLSAT QNILSLNSPT TMENTMPNAT
     351  FQISMADNTT TAQMHPNRKP SQIAYDASFS NSAKGSQPLF DKSQNMYHAL
     401  DPPLVEPLAS SVSNNDNELK ANSATKLKQA IVSEAHTFRQ NNSIDFPLQN
     451  IIPQYEDSSS SSDESYSGDV DELKKTRSLG SYSTRGNIKK NQSVKESLTS
     501  SSLPGTSFTP TSTKVNLKHE NSPFKSTFVN TIDNSKDDLN KPSYEDLDVS
     551  KQNLKNSIQQ RMIDKLNSSE ESFNARKMSK VKLHEKGEID KPTMLKSSGP
     601  ISKDKKTKPT PPPKPSHLKP KPPPKPLLLA GRKLSLDK*

external links for Ark1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Ark1p

1)	Cope MJ, et al. (1999) Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast. J Cell Biol 144(6):1203-18
2)	Smythe E and Ayscough KR (2003) The Ark1/Prk1 family of protein kinases. Regulators of endocytosis and the actin skeleton. EMBO Rep 4(3):246-51
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41