HEF3/YNL014W Protein Information Help

Standard Name Hef3p
Systematic Name Ynl014wp
Alias Zrg7p 1
ORF Classification Verified
Description Translational elongation factor EF-3; member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells; HEF3 has a paralog, YEF3, that arose from the whole genome duplication (1, 2, 3, 4)
Name Description Homolog of EF-3 2
Experimental Data
Molecules/cell 125 5
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 1,044
Molecular Weight (Da) 115,868
Isoelectric Point (pI) 6.16

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hef3p (InterPro)
Physical Interactions There are 25 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001683FE | P53978
MIPS: YNL014W
NCBI: 1301836 | 1706591 | 398365455 | NP_014384.3 | NM_001182853.3
GenBank/EMBL/DDBJ: DAA10530.1 | Z71290
Amino Acid Sequence (or in FASTA format)
 
       1  MSDSQQSITV LEELFRKLET ATSETREGIS SELSSFLNGN IIEHDVPEVF
      51  FDEFQKAIQS KQKALNTLGA VAYIANETNL SPSVEPYIVA TVPSVCSKAG
     101  SKDNDVQLAA TKALKAIASA VNPVAVKALL PHLIHSLETS NKWKEKVAVL
     151  EVISVLVDAA KEQIALRMPE LIPVLSESMW DTKKGVKEAA TTTITKATET
     201  VDNKDIERFI PKLIECIANP NEVPETVHLL GATTFVAEVT PATLSIMVPL
     251  LSRGLAERET SIKRKAAVII DNMCKLVEDP QVVAPFLGKL LPGLKNNFAT
     301  IADPEAREVT LKALKTLRRV GNVGEDDVLP EISHAGDVST TLGVIKELLE
     351  PEKVAPRFTI VVEYIAAIAA NLIDERIIDQ QTWFTHVTPY MTIFLHEKTA
     401  KEILDDFRKR AVDNIPVGPN FQDEEDEGED LCNCEFSLAY GAKILLNKTQ
     451  LRLKRGRRYG LCGPNGAGKS TLMRSIANGQ VDGFPTQDEC RTVYVEHDID
     501  NTHSDMSVLD FVYSGNVGTK DVITSKLKEF GFSDEMIEMP IASLSGGWKM
     551  KLALARAVLK DADILLLDEP TNHLDTVNVE WLVNYLNTCG ITSVIVSHDS
     601  GFLDKVCQYI IHYEGLKLRK YKGNLSEFVQ KCPTAQSYYE LGASDLEFQF
     651  PTPGYLEGVK TKQKAIVKVS NMTFQYPGTT KPQVSDVTFQ CSLSSRIAVI
     701  GPNGAGKSTL INVLTGELLP TSGEVYTHEN CRIAYIKQHA FAHIESHLDK
     751  TPSEYIQWRF QTGEDRETMD RANRQINEND AEAMNKIFKI EGTPRRVAGI
     801  HSRRKFKNTY EYECSFLLGE NIGMKSERWV PMMSVDNAWL PRGELIESHS
     851  KMVAEIDMKE ALASGQFRAL TRKEIELHCA MLGLDSELVS HSRIRGLSGG
     901  QKVKLVLAAC TWQRPHLIVL DEPTNYLDRD SLGALSKALK AFEGGVIIIT
     951  HSAEFTKNLT DEVWAVKDGK MTPSGHNWVA GQGAGPRIEK KEEEGDKFDA
    1001  MGNKINSGKK KSKLSSAELR KKKKERMKKK KEMGDEYVSS DEDF*

external links for Hef3p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Candida (CGD) BioPIXIE MIPS YeastGFP
Candida (CandidaDB) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
YGOB Complexome YeastRC Structure Prediction (Seattle)
YOGY DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hef3p
1) Yuan DS  (2000) Zinc-regulated genes in Saccharomyces cerevisiae revealed by transposon tagging. Genetics 156(1):45-58
2) Maurice TC, et al.  (1998) A highly conserved intraspecies homolog of the Saccharomyces cerevisiae elongation factor-3 encoded by the HEF3 gene. Yeast 14(12):1105-13
3) Sarthy AV, et al.  (1998) Identification and kinetic analysis of a functional homolog of elongation factor 3, YEF3 in Saccharomyces cerevisiae. Yeast 14(3):239-53
4) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
5) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41