FET4/YMR319C Protein Information

Standard Name	Fet4p 1
Systematic Name	Ymr319cp
ORF Classification	Verified
Description	Low-affinity Fe(II) transporter of the plasma membrane (1, 2)
Name Description	FErrous Transport 1

Experimental Data
Molecules/cell	573 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	552
Molecular Weight (Da)	62,791
Isoelectric Point (pI)	5.26

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Fet4p (InterPro)
Transmembrane Domains	There are 7 total predicted transmembrane domains (TMHMM)
Physical Interactions	There are 23 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012A6F7 \| P40988 MIPS: YMR319C NCBI: 1706786 \| 567911 \| 6323981 \| 984692 \| NP_014052.1 GenBank/EMBL/DDBJ: DAA10221.1 \| L34837 \| Z54141

Amino Acid Sequence (or in FASTA format)
1 MGKIAEFLGN PGARPDVHHR APTVDCKQYE EFGDSNDYKN DDVVRVVSHS 51 DESTDDELCN VNLTETGAIF TSKGFTGLSK GFTDKTLDFL VRVAGSQAVF 101 FIVWIILIIW VVIGIVYNAP FNWQVVMQDG QSIQSYVWDT LLMRQQLMST 151 HEQILICGRL KSRLASFKNY LTRSTPEEEK ADCTVEANEV SSVENHIDPS 201 AINGELPVEN WYDRLSNVAS RYMGSIAAMV IFWIGIFVWI GCGAIPKDAG 251 NTPPYTGETT GSNPRLKKFS DAWQMYINTA VAVSLLICTT FLQNIRARHD 301 YFTGRFLVDI FDMDEKIDYR IRKHFNDFET PHPVVTIESK KRSTGRKMID 351 WYADIIGTGI GVLIGVAVFA TWIGIGSPMK WDDNWWLIIG TYTGLIGFLD 401 GFVLREVYFR IVQHEEKNYS DVAKEDLELF QELGIECPEE FSGKAPEINT 451 IGYRTSQYIN RICSTPWSVL VSVIIIIGLI CIASGLRWST TGQLIANTPT 501 MIIEEFFLLV LLQAHNWADR QRRVEVTALY ARRRILLSYV EKRFPEVMML 551 EK*

Amino Acid Sequence (or in FASTA format)

       1  MGKIAEFLGN PGARPDVHHR APTVDCKQYE EFGDSNDYKN DDVVRVVSHS
      51  DESTDDELCN VNLTETGAIF TSKGFTGLSK GFTDKTLDFL VRVAGSQAVF
     101  FIVWIILIIW VVIGIVYNAP FNWQVVMQDG QSIQSYVWDT LLMRQQLMST
     151  HEQILICGRL KSRLASFKNY LTRSTPEEEK ADCTVEANEV SSVENHIDPS
     201  AINGELPVEN WYDRLSNVAS RYMGSIAAMV IFWIGIFVWI GCGAIPKDAG
     251  NTPPYTGETT GSNPRLKKFS DAWQMYINTA VAVSLLICTT FLQNIRARHD
     301  YFTGRFLVDI FDMDEKIDYR IRKHFNDFET PHPVVTIESK KRSTGRKMID
     351  WYADIIGTGI GVLIGVAVFA TWIGIGSPMK WDDNWWLIIG TYTGLIGFLD
     401  GFVLREVYFR IVQHEEKNYS DVAKEDLELF QELGIECPEE FSGKAPEINT
     451  IGYRTSQYIN RICSTPWSVL VSVIIIIGLI CIASGLRWST TGQLIANTPT
     501  MIIEEFFLLV LLQAHNWADR QRRVEVTALY ARRRILLSYV EKRFPEVMML
     551  EK*

external links for Fet4p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Fet4p

1)	Dix DR, et al. (1994) The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae. J Biol Chem 269(42):26092-9
2)	Hassett R, et al. (2000) The Fe(II) permease Fet4p functions as a low affinity copper transporter and supports normal copper trafficking in Saccharomyces cerevisiae. Biochem J 351 Pt 2():477-84
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41