YMR315W Protein Information

Systematic Name	Ymr315wp
ORF Classification	Verified
Description	Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site; protein abundance increases in response to DNA replication stress (1, 2, 3, 4)

Experimental Data
Molecules/cell	9600 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	349
Molecular Weight (Da)	38,215
Isoelectric Point (pI)	6.61

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ymr315wp (InterPro)
Physical Interactions	There are 17 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI00000532A7 \| Q04869 MIPS: YMR315W NCBI: 2497226 \| 45269872 \| 6323975 \| 984688 \| NP_014046.1 GenBank/EMBL/DDBJ: DAA10216.1 \| AY557991 \| Z54141

Amino Acid Sequence (or in FASTA format)
1 MSPLNVGIVG TGIFARDRHL PSYQEFPDKF KVIAAFNRHK AKALDFAKVA 51 DIPENKVYDN LDEILNDPHV DYIDALLPAQ FNADIVEKAV KAGKPVILEK 101 PIAANLDQAK EIVKIAESTP LPVGVAENWL YLPCIKIAKE QIEKIGPVVA 151 FTHNSTGPFV TQNKYLTTTW RQKPEHIGGF LSDGGVHQLA LVISLLGEFG 201 SVSALTRQVR ERSGADDIVF ATVQLKNKEV IGSFTYGSAF GATEKSVFLK 251 VYGKNGTVTV DLSDKKDPVV KVKLGGSAED NGDEQIFKVD NDESFGVNAE 301 FLNFHEAVSK KDKSLYLGTP RTAFHHLACV DAFLKSSAKN GDYVKIEQP*

Amino Acid Sequence (or in FASTA format)

       1  MSPLNVGIVG TGIFARDRHL PSYQEFPDKF KVIAAFNRHK AKALDFAKVA
      51  DIPENKVYDN LDEILNDPHV DYIDALLPAQ FNADIVEKAV KAGKPVILEK
     101  PIAANLDQAK EIVKIAESTP LPVGVAENWL YLPCIKIAKE QIEKIGPVVA
     151  FTHNSTGPFV TQNKYLTTTW RQKPEHIGGF LSDGGVHQLA LVISLLGEFG
     201  SVSALTRQVR ERSGADDIVF ATVQLKNKEV IGSFTYGSAF GATEKSVFLK
     251  VYGKNGTVTV DLSDKKDPVV KVKLGGSAED NGDEQIFKVD NDESFGVNAE
     301  FLNFHEAVSK KDKSLYLGTP RTAFHHLACV DAFLKSSAKN GDYVKIEQP*

external links for Ymr315wp

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastRC Public Image Repository
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA

References cited on this page View Complete Literature Guide for Ymr315wp

1)	Giaever G, et al. (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
2)	Huh WK, et al. (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
3)	Hector RE, et al. (2009) The Saccharomyces cerevisiae YMR315W gene encodes an NADP(H)-specific oxidoreductase regulated by the transcription factor Stb5p in response to NADPH limitation. N Biotechnol 26(3-4):171-80
4)	Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41