ELP6/YMR312W Protein Information

Standard Name	Elp6p 1, 2
Systematic Name	Ymr312wp
Alias	Hap3p , Tot6p 3 , Kti4p 4
ORF Classification	Verified
Description	Subunit of hexameric RecA-like ATPase Elp456 Elongator subcomplex; which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity (5, 6, 7, 8)
Name Description	ELongator Protein 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	273
Molecular Weight (Da)	30,573
Isoelectric Point (pI)	6.67

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Elp6p (InterPro)
Physical Interactions	There are 33 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000013B94D \| Q04868 MIPS: YMR312W NCBI: 2497225 \| 377656547 \| 377656550 \| 385867882 \| 45269856 \| 6323972 \| 984685 \| NP_014043.1 GenBank/EMBL/DDBJ: DAA10213.1 \| AY557983 \| Z54141

Amino Acid Sequence (or in FASTA format)
1 MGSVQRQDLV LFSDQSVLPA HFFQDSNSHN LFFITHQSCT QPLWMINALV 51 ETHVLGSPSS LNESSSSMLP SSTRSHAVLA SFIHEQNYFT NSLNKLKIPS 101 NNYNVLDFLS DFIVNNIHNK PRDKILSDVL AKFSAAIQNN PTDTIVIIEQ 151 PELLLSLVSG LTCSELNNKF ITPLLRQCKV LIIVSNSDIF NIDEYDASVH 201 SSNLQNFYKS SFIKSMINLN LNPLKTGFAK DVTGSLHVCR GGAPIATSNT 251 SLHVVENEYL YLNEKESTKL FYR*

Amino Acid Sequence (or in FASTA format)

       1  MGSVQRQDLV LFSDQSVLPA HFFQDSNSHN LFFITHQSCT QPLWMINALV
      51  ETHVLGSPSS LNESSSSMLP SSTRSHAVLA SFIHEQNYFT NSLNKLKIPS
     101  NNYNVLDFLS DFIVNNIHNK PRDKILSDVL AKFSAAIQNN PTDTIVIIEQ
     151  PELLLSLVSG LTCSELNNKF ITPLLRQCKV LIIVSNSDIF NIDEYDASVH
     201  SSNLQNFYKS SFIKSMINLN LNPLKTGFAK DVTGSLHVCR GGAPIATSNT
     251  SLHVVENEYL YLNEKESTKL FYR*

external links for Elp6p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains
YGOB	Complexome
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Elp6p

1)	Winkler GS, et al. (2001) RNA polymerase II elongator holoenzyme is composed of two discrete subcomplexes. J Biol Chem 276(35):32743-9
2)	Krogan NJ and Greenblatt JF (2001) Characterization of a six-subunit holo-elongator complex required for the regulated expression of a group of genes in Saccharomyces cerevisiae. Mol Cell Biol 21(23):8203-12
3)	Jablonowski D, et al. (2001) Kluyveromyces lactis zymocin mode of action is linked to RNA polymerase II function via Elongator. Mol Microbiol 42(4):1095-105
4)	Butler AR, et al. (1991) Intracellular expression of Kluyveromyces lactis toxin gamma subunit mimics treatment with exogenous toxin and distinguishes two classes of toxin-resistant mutant. Yeast 7(6):617-25
5)	Winkler GS, et al. (2002) Elongator is a histone H3 and H4 acetyltransferase important for normal histone acetylation levels in vivo. Proc Natl Acad Sci U S A 99(6):3517-22
6)	Frohloff F, et al. (2003) Subunit communications crucial for the functional integrity of the yeast RNA polymerase II elongator (gamma-toxin target (TOT)) complex. J Biol Chem 278(2):956-61
7)	Esberg A, et al. (2006) Elevated levels of two tRNA species bypass the requirement for elongator complex in transcription and exocytosis. Mol Cell 24(1):139-48
8)	Glatt S, et al. (2012) The Elongator subcomplex Elp456 is a hexameric RecA-like ATPase.LID - 10.1038/nsmb.2234 [doi] Nat Struct Mol Biol ()