HER2/YMR293C Protein Information Help

Standard Name Her2p 1
Systematic Name Ymr293cp
Alias Gep6p 2 , Rrg6p 3
ORF Classification Verified
Description Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase (1, 2, 4, 5, 6, 7)
Name Description Hmg2p ER Remodeling 1
Experimental Data
Molecules/cell 486 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 464
Molecular Weight (Da) 50,918
Isoelectric Point (pI) 8.88

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Her2p (InterPro)
Physical Interactions There are 2 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000012B1AE | Q03557
MIPS: YMR293C
NCBI: 2492830 | 530350 | 6323950 | NP_014021.1
GenBank/EMBL/DDBJ: DAA10194.1 | X80836
External Classifications EC: 3.5.1.4 [Amidase]
EC: 6.3.5.- [Carbon-Nitrogen Ligases with Glutamine as Amido-N-Donor]
Amino Acid Sequence (or in FASTA format)
 
       1  MPLKRSLKES IERLSSFQSK YNIFTSINPS PYSITNKKGT KETLTGCVAS
      51  IKDNIVTKDF PTTCASHILE NFKSPFDATV VKLLKQAGVH ILGKTNLDEF
     101  GMGSGGVHSI RGPVINPLYP HEDKKIMGGS SSGAAASVAC DLVDFALGTD
     151  TGGSVRLPAC YGSVLGFKPS YGRLSRFGVI AYSQSLDTVG ILSKKINVLR
     201  KVFHTLDKYD MKDPTSLSVE LRELIEGNKK VRRPLKVGIV KEFSHESMPI
     251  GFHRLYLSLL EKLINLGLEI YPVSIPSVKN CLPIYYTLSP AEAASNLSRY
     301  DGIRYGYRDS ELDIKDGILF APTRSKFGTE VKNRIILGNY NLCSDAFKNN
     351  FIKAEKLRVN LIDEFDGIFR FPNVLTNSKG NPDGLDLLIV PTSSKLPGSI
     401  RDFEEEEAKS PANSYINDVF TVPMSLAGLP SLSMPLKEKT PIGLQVVGQY
     451  GDDSTVLDFV ESIS*

external links for Her2p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains YeastRC Public Image Repository
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA


YeastRC Two-Hybrid (Seattle)

References cited on this page View Complete Literature Guide for Her2p
1) Federovitch CM, et al.  (2008) Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Mol Biol Cell 19(10):4506-20
2) Osman C, et al.  (2009) The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria. J Cell Biol 184(4):583-96
3) Merz S and Westermann B  (2009) Genome-wide deletion mutant analysis reveals genes required for respiratory growth, mitochondrial genome maintenance and mitochondrial protein synthesis in Saccharomyces cerevisiae. Genome Biol 10(9):R95
4) Giaever G, et al.  (2002) Functional profiling of the Saccharomyces cerevisiae genome. Nature 418(6896):387-91
5) Huh WK, et al.  (2003) Global analysis of protein localization in budding yeast. Nature 425(6959):686-91
6) Reinders J, et al.  (2006) Toward the complete yeast mitochondrial proteome: multidimensional separation techniques for mitochondrial proteomics. J Proteome Res 5(7):1543-54
7) Frechin M, et al.  (2009) Yeast mitochondrial Gln-tRNA(Gln) is generated by a GatFAB-mediated transamidation pathway involving Arc1p-controlled subcellular sorting of cytosolic GluRS. Genes Dev 23(9):1119-30
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41