HAS1/YMR290C Protein Information Help

Standard Name Has1p
Systematic Name Ymr290cp
ORF Classification Verified
Description ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles (1, 2, 3)
Name Description Helicase Associated with Set1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 505
Molecular Weight (Da) 56,717
Isoelectric Point (pI) 10.13

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Has1p (InterPro)
Physical Interactions There are 235 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI0000052F14 | Q03532
MIPS: YMR290C
NCBI: 2500537 | 530347 | 6323947 | NP_014017.1
GenBank/EMBL/DDBJ: DAA10191.1 | X80836
External Classifications EC: 3.6.1.- [Hydrolases acting on acid anhydrides in phosphorous-containing anhydrides]
Amino Acid Sequence (or in FASTA format)
 
       1  MATPSNKRSR DSESTEEPVV DEKSTSKQNN AAPEGEQTTC VEKFEELKLS
      51  QPTLKAIEKM GFTTMTSVQA RTIPPLLAGR DVLGAAKTGS GKTLAFLIPA
     101  IELLHSLKFK PRNGTGIIVI TPTRELALQI FGVARELMEF HSQTFGIVIG
     151  GANRRQEAEK LMKGVNMLIA TPGRLLDHLQ NTKGFVFKNL KALIIDEADR
     201  ILEIGFEDEM RQIIKILPNE DRQSMLFSAT QTTKVEDLAR ISLRPGPLFI
     251  NVVPETDNST ADGLEQGYVV CDSDKRFLLL FSFLKRNQKK KIIVFLSSCN
     301  SVKYYAELLN YIDLPVLELH GKQKQQKRTN TFFEFCNAER GILICTDVAA
     351  RGLDIPAVDW IIQFDPPDDP RDYIHRVGRT ARGTKGKGKS LMFLTPNELG
     401  FLRYLKASKV PLNEYEFPEN KIANVQSQLE KLIKSNYYLH QTAKDGYRSY
     451  LQAYASHSLK TVYQIDKLDL AKVAKSYGFP VPPKVNITIG ASGKTPNTKR
     501  RKTHK*

external links for Has1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
Aspergillus (AspGD) BioPIXIE MIPS YeastGFP
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Has1p
1) Rout MP, et al.  (2000) The yeast nuclear pore complex: composition, architecture, and transport mechanism. J Cell Biol 148(4):635-51
2) Horsey EW, et al.  (2004) Role of the yeast Rrp1 protein in the dynamics of pre-ribosome maturation. RNA 10(5):813-27
3) Rocak S, et al.  (2005) Characterization of the ATPase and unwinding activities of the yeast DEAD-box protein Has1p and the analysis of the roles of the conserved motifs. Nucleic Acids Res 33(3):999-1009