HSH155/YMR288W Protein Information Help

Standard Name Hsh155p 1
Systematic Name Ymr288wp
ORF Classification Verified
Description U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 (1, 2, 3)
Name Description Human Sap Homolog 1
Experimental Data
Molecules/cell 521 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 971
Molecular Weight (Da) 110,027
Isoelectric Point (pI) 7.25

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Hsh155p (InterPro)
Physical Interactions There are 97 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000531EC | P49955
MIPS: YMR288W
NCBI: 1730609 | 6323944 | 825554 | NP_014015.1
GenBank/EMBL/DDBJ: DAA10189.1 | Z49704
Amino Acid Sequence (or in FASTA format)
 
       1  MSHPIQFVNA NNSDKSHQLG GQYSIPQDLR ENLQKEAARI GENEKDVLQE
      51  KMETRTVQNR EDSYHKRRFD MKFEPDSDTQ TVTSSENTQD AVVPRKRKSR
     101  WDVKGYEPPD ESSTAVKENS DSALVNVEGI HDLMFFKPSD HKYFADVISK
     151  KPIDELNKDE KKERTLSMLL LKIKNGNTAS RRTSMRILTD KAVTFGPEMI
     201  FNRLLPILLD RSLEDQERHL MIKTIDRVLY QLGDLTKPYV HKILVVAAPL
     251  LIDEDPMVRS TGQEIITNLS TVAGLKTILT VMRPDIENED EYVRNVTSRA
     301  AAVVAKALGV NQLLPFINAA CHSRKSWKAR HTGIKIVQQI GILLGIGVLN
     351  HLTGLMSCIK DCLMDDHVPV RIVTAHTLST LAENSYPYGI EVFNVVLEPL
     401  WKGIRSHRGK VLSSFLKAVG SMIPLMDPEY AGYYTTEAMR IIRREFDSPD
     451  DEMKKTILLV LQKCSAVESI TPKFLREEIA PEFFQKFWVR RVALDRPLNK
     501  VVTYTTVTLA KKLGCSYTID KLLTPLRDEA EPFRTMAVHA VTRTVNLLGT
     551  ADLDERLETR LIDALLIAFQ EQTNSDSIIF KGFGAVTVSL DIRMKPFLAP
     601  IVSTILNHLK HKTPLVRQHA ADLCAILIPV IKNCHEFEML NKLNIILYES
     651  LGEVYPEVLG SIINAMYCIT SVMDLDKLQP PINQILPTLT PILRNKHRKV
     701  EVNTIKFVGL IGKLAPTYAP PKEWMRICFE LLELLKSTNK EIRRSANATF
     751  GFIAEAIGPH DVLVALLNNL KVQERQLRVC TAVAIGIVAK VCGPYNVLPV
     801  IMNEYTTPET NVQNGVLKAM SFMFEYIGNM SKDYIYFITP LLEDALTDRD
     851  LVHRQTASNV ITHLALNCSG TGHEDAFIHL MNLLIPNIFE TSPHAIMRIL
     901  EGLEALSQAL GPGLFMNYIW AGLFHPAKNV RKAFWRVYNN MYVMYQDAMV
     951  PFYPVTPDNN EEYIEELDLV L*

external links for Hsh155p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Hsh155p
1) Pauling MH, et al.  (2000) Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. Mol Cell Biol 20(6):2176-85
2) Stevens SW, et al.  (2002) Composition and functional characterization of the yeast spliceosomal penta-snRNP. Mol Cell 9(1):31-44
3) McPheeters DS and Muhlenkamp P  (2003) Spatial organization of protein-RNA interactions in the branch site-3' splice site region during pre-mRNA splicing in yeast. Mol Cell Biol 23(12):4174-86
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41