AEP2/YMR282C Protein Information

Standard Name	Aep2p 1
Systematic Name	Ymr282cp
Alias	Atp13p
ORF Classification	Verified
Description	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader (1, 2, 3)
Name Description	ATPase ExPression 1

Experimental Data
Molecules/cell	2680 4

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	580
Molecular Weight (Da)	67,523
Isoelectric Point (pI)	10.33

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Aep2p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053264 \| P22136 MIPS: YMR282C NCBI: 1352052 \| 171034 \| 556676 \| 5679710 \| 6323938 \| 825548 \| NP_014009.1 GenBank/EMBL/DDBJ: DAA10183.1 \| M59860 \| X56215 \| X80795 \| Z49704

Amino Acid Sequence (or in FASTA format)
1 MWINRLVKHP SYSVLRFYTK RLCTVSVKSL REFGVLPNST ICHSVYPRRT 51 YVMGRAVIND ILIKKSYSTH TVCAIDRSKD ENNGSAYDKF EAKGIPIDVH 101 TLKRIISSSG MDESEFSKSI SYLFAKTVDP EPKDVLSLED LSFLLSKLYT 151 QRFQIRRICR DINAKYSEFW FKLFSLYAEK VDAKRNQVNL RNTKLDACEI 201 FDANLMIKNF IELGQLGKAQ KILSFILDRN PDILLSPKNA DISTIVHFLQ 251 LRCGALAPYW KIPDNSEQKQ GFLRKMVRLG AKNTSIRLSS TYKAMDHQTL 301 LKIADLALQE KKLLNSEDLL STLIQSFGHL GQTQILERCI EHIWQISPQE 351 FPSHVVIKHR GCYPSSKILV SILVSFYFND HDLHRGLSIL DSFIKHYPDV 401 KLDALFWRRL FQLSHFAWTP ANDKKATSVV RCWHLMKQWY ASKRLRPSVD 451 YETLRQLYDI MKKTGNFPLG IDVLRSFKPG IERTRAENAG KVNNIIIKYQ 501 KCIIKELVNR GRFSAVREFI DSYGFDRKMT KDLNIFCANR MFLRSKKMKN 551 KIENKKEREK VRLDSFDDDE DDGMIIGSLW *

Amino Acid Sequence (or in FASTA format)

       1  MWINRLVKHP SYSVLRFYTK RLCTVSVKSL REFGVLPNST ICHSVYPRRT
      51  YVMGRAVIND ILIKKSYSTH TVCAIDRSKD ENNGSAYDKF EAKGIPIDVH
     101  TLKRIISSSG MDESEFSKSI SYLFAKTVDP EPKDVLSLED LSFLLSKLYT
     151  QRFQIRRICR DINAKYSEFW FKLFSLYAEK VDAKRNQVNL RNTKLDACEI
     201  FDANLMIKNF IELGQLGKAQ KILSFILDRN PDILLSPKNA DISTIVHFLQ
     251  LRCGALAPYW KIPDNSEQKQ GFLRKMVRLG AKNTSIRLSS TYKAMDHQTL
     301  LKIADLALQE KKLLNSEDLL STLIQSFGHL GQTQILERCI EHIWQISPQE
     351  FPSHVVIKHR GCYPSSKILV SILVSFYFND HDLHRGLSIL DSFIKHYPDV
     401  KLDALFWRRL FQLSHFAWTP ANDKKATSVV RCWHLMKQWY ASKRLRPSVD
     451  YETLRQLYDI MKKTGNFPLG IDVLRSFKPG IERTRAENAG KVNNIIIKYQ
     501  KCIIKELVNR GRFSAVREFI DSYGFDRKMT KDLNIFCANR MFLRSKKMKN
     551  KIENKKEREK VRLDSFDDDE DDGMIIGSLW *

external links for Aep2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Aep2p

1)	Payne MJ, et al. (1991) Properties of two nuclear pet mutants affecting expression of the mitochondrial oli1 gene of Saccharomyces cerevisiae. Curr Genet 19(5):343-51
2)	Ellis TP, et al. (1999) Suppression of a nuclear aep2 mutation in Saccharomyces cerevisiae by a base substitution in the 5'-untranslated region of the mitochondrial oli1 gene encoding subunit 9 of ATP synthase. Genetics 151(4):1353-63
3)	Finnegan PM, et al. (1995) The mature AEP2 gene product of Saccharomyces cerevisiae, required for the expression of subunit 9 of ATP synthase, is a 58 kDa mitochondrial protein. FEBS Lett 368(3):505-8
4)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41