CAT8/YMR280C Protein Information 
| Standard Name | Cat8p 1 |
|---|---|
| Systematic Name | Ymr280cp |
| Alias | Dil1p 2 , Msp8p |
| ORF Classification | Verified |
| Description | Zinc cluster transcriptional activator; necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements; relative distribution to the nucleus increases upon DNA replication stress (1, 3, 4, 5, 6, 7, 8, 9) |
| Name Description | CATabolite repression 10 |
| Click on image for expanded interactive view |
|---|
| Post-translational Modifications | PhosphoGRID | PhosphoPep Database |
|---|---|
| Domains/motifs | See the graphical view and list of proteins that share domains/motifs in common with Cat8p (InterPro) |
| Physical Interactions | There are 16 total physical interactions (BioGRID) |
| Homologs | PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer |
| External Sequence Databases |
EBI: UPI0000127044 | P39113 MIPS: YMR280C NCBI: 1122901 | 1705619 | 559524 | 6323936 | 825546 | NP_014007.1 | NM_001182787.1 GenBank/EMBL/DDBJ: DAA10181.1 | X78344 | X94215 | Z49704 |
external links for Cat8p
| Homologs | Interaction Resources | Protein databases/Other | Localization Resources |
|---|---|---|---|
| BLASTP (NCBI) | BioGRID | SCOP Superfamily | YPL+ |
| Ashbya (AGD) | BOND | GPMdb (Mass Spec.) | YeastGFP |
| Candida (CGD) | BioPIXIE | MIPS | YeastRC Public Image Repository |
| Candida (CandidaDB) | CYC2008 (complexes) | Pfam domains | |
| YGOB | Complexome | YeastRC Structure Prediction (Seattle) | |
| YOGY | DIP | ||
| GeneMANIA |
References cited on this page View Complete Literature Guide for Cat8p
| 1) | Hedges D, et al. (1995) CAT8, a new zinc cluster-encoding gene necessary for derepression of gluconeogenic enzymes in the yeast Saccharomyces cerevisiae. Mol Cell Biol 15(4):1915-22 |
| 2) | Rahner A, et al. (1996) Dual influence of the yeast Cat1p (Snf1p) protein kinase on carbon source-dependent transcriptional activation of gluconeogenic genes by the regulatory gene CAT8. Nucleic Acids Res 24(12):2331-7 |
| 3) | Haurie V, et al. (2001) The transcriptional activator Cat8p provides a major contribution to the reprogramming of carbon metabolism during the diauxic shift in Saccharomyces cerevisiae. J Biol Chem 276(1):76-85 |
| 4) | Bojunga N and Entian KD (1999) Cat8p, the activator of gluconeogenic genes in Saccharomyces cerevisiae, regulates carbon source-dependent expression of NADP-dependent cytosolic isocitrate dehydrogenase (Idp2p) and lactate permease (Jen1p). Mol Gen Genet 262(4-5):869-75 |
| 5) | Vincent O and Carlson M (1998) Sip4, a Snf1 kinase-dependent transcriptional activator, binds to the carbon source-responsive element of gluconeogenic genes. EMBO J 17(23):7002-8 |
| 6) | Bojunga N, et al. (1998) The succinate/fumarate transporter Acr1p of Saccharomyces cerevisiae is part of the gluconeogenic pathway and its expression is regulated by Cat8p. Mol Gen Genet 260(5):453-61 |
| 7) | Hiesinger M, et al. (2001) Contribution of Cat8 and Sip4 to the transcriptional activation of yeast gluconeogenic genes by carbon source-responsive elements. Curr Genet 39(2):68-76 |
| 8) | Young ET, et al. (2003) Multiple pathways are co-regulated by the protein kinase Snf1 and the transcription factors Adr1 and Cat8. J Biol Chem 278(28):26146-58 |
| 9) | Tkach JM, et al. (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76 |
| 10) | Zimmermann FK, et al. (1977) Genetics of carbon catabolite repression in Saccharomycess cerevisiae: genes involved in the derepression process. Mol Gen Genet 151(1):95-103 |
