FCP1/YMR277W Protein Information Help

Standard Name Fcp1p 1
Systematic Name Ymr277wp
ORF Classification Verified
Description Carboxy-terminal domain (CTD) phosphatase; essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p); relocalizes to the cytosol in response to hypoxia (2, 3)
Name Description tfiiF-associating component of Ctd Phosphatase 1
Experimental Data
Molecules/cell 6550 4
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 732
Molecular Weight (Da) 83,440
Isoelectric Point (pI) 4.38

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Fcp1p (InterPro)
Physical Interactions There are 35 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000013B940 | Q03254
MIPS: YMR277W
NCBI: 2497216 | 6323933 | 825543 | NP_014004.1 | NM_001182784.1
GenBank/EMBL/DDBJ: CAA89775.1 | DAA10178.1 | Z49704
External Classifications EC: 3.1.3.16 [Protein-serine/threonine phosphatase]
Amino Acid Sequence (or in FASTA format)
       1  MTTQIRSPQG LPYPIQIDKL IPSVGSYLHE GDRLLVYKFW YLVERASDTG
      51  DDDNEHDVSP GGSAGSNGVS PPTKQLRESI EFFESPYEGD LISWNVDVGD
     101  EVATANQVIC EIKRPCNHDI VYGGLCTQCG KEVSADAFDG VPLDVVGDVD
     151  LQISETEAIR TGKALKEHLR RDKKLILVVD LDQTIIHCGV DPTIAEWKND
     201  PNNPNFETLR DVKSFTLDEE LVLPLMYMND DGSMLRPPPV RKCWYYVKVR
     251  PGLKEFFAKV APLFEMHIYT MATRAYALQI AKIVDPTGEL FGDRILSRDE
     301  NGSLTTKSLA KLFPTDQSMV VVIDDRGDVW NWCPNLIKVV PYNFFVGVGD
     351  INSNFLPKQS TGMLQLGRKT RQKSQESQEL LTDIMDNEKK LQEKIDKEVK
     401  RQEEKLNHQL ATAEEPPANE SKEELTKKLE YSASLEVQQQ NRPLAKLQKH
     451  LHDQKLLVDD DDELYYLMGT LSNIHKTYYD MLSQQNEPEP NLMEIIPSLK
     501  QKVFQNCYFV FSGLIPLGTD IQRSDIVIWT STFGATSTPD IDYLTTHLIT
     551  KNPSTYKARL AKKFNPQIKI VHPDWIFECL VNWKKVDEKP YTLIVDSPIS
     601  DEELQNFQTQ LQKRQEYLEE TQEQQHMLTS QENLNLFAAG TSWLNNDDDE
     651  DIPDTASDDD EDDDHDDESD DENNSEGIDR KRSIEDNHDD TSQKKTKAEP
     701  SQDGPVQHKG EGDDNEDSDS QLEEELMDML DD*                  

external links for Fcp1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Candida (CGD) CYC2008 (complexes) MIPS YeastRC Public Image Repository
YGOB Complexome Pfam domains
YOGY DIP YeastRC Structure Prediction (Seattle)

GeneMANIA


IMP

References cited on this page View Complete Literature Guide for Fcp1p
1) Archambault J, et al.  (1997) An essential component of a C-terminal domain phosphatase that interacts with transcription factor IIF in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A 94(26):14300-5
2) Kops O, et al.  (2002) Pin1 modulates the dephosphorylation of the RNA polymerase II C-terminal domain by yeast Fcp1. FEBS Lett 513(2-3):305-11
3) Ghosh Dastidar R, et al.  (2012) The nuclear localization of SWI/SNF proteins is subjected to oxygen regulation. Cell Biosci 2(1):30
4) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41