SAP30/YMR263W Protein Information

Standard Name	Sap30p
Systematic Name	Ymr263wp
ORF Classification	Verified
Description	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance (1, 2, 3, 4)
Name Description	SIT4 protein phosphatase Associated Protein

Experimental Data
Molecules/cell	704 5

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	201
Molecular Weight (Da)	23,026
Isoelectric Point (pI)	10.53

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Sap30p (InterPro)
Physical Interactions	There are 77 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053138 \| P38429 MIPS: YMR263W NCBI: 173196 \| 2506767 \| 45269836 \| 6323919 \| 809086 \| NP_013990.1 GenBank/EMBL/DDBJ: DAA10163.1 \| AY557972 \| M88172 \| Z49260

Amino Acid Sequence (or in FASTA format)
1 MARPVNTNAE TESRGRPTQG GGYASNNNGS CNNNNGSNNN NNNNNNNNNN 51 SNNSNNNNGP TSSGRTNGKQ RLTAAQQQYI KNLIETHITD NHPDLRPKSH 101 PMDFEEYTDA FLRRYKDHFQ LDVPDNLTLQ GYLLGSKLGA KTYSYKRNTQ 151 GQHDKRIHKR DLANVVRRHF DEHSIKETDC IPQFIYKVKN QKKKFKMEFR 201 G*

Amino Acid Sequence (or in FASTA format)

       1  MARPVNTNAE TESRGRPTQG GGYASNNNGS CNNNNGSNNN NNNNNNNNNN
      51  SNNSNNNNGP TSSGRTNGKQ RLTAAQQQYI KNLIETHITD NHPDLRPKSH
     101  PMDFEEYTDA FLRRYKDHFQ LDVPDNLTLQ GYLLGSKLGA KTYSYKRNTQ
     151  GQHDKRIHKR DLANVVRRHF DEHSIKETDC IPQFIYKVKN QKKKFKMEFR
     201  G*

external links for Sap30p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Candida (CGD)	BioPIXIE	MIPS	YeastGFP
Candida (CandidaDB)	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
YGOB	Complexome
YOGY	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Sap30p

1)	Sun ZW and Hampsey M (1999) A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Genetics 152(3):921-32
2)	Zhang Y, et al. (1998) SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Mol Cell 1(7):1021-31
3)	Bernstein BE, et al. (2000) Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A 97(25):13708-13
4)	Askree SH, et al. (2004) A genome-wide screen for Saccharomyces cerevisiae deletion mutants that affect telomere length. Proc Natl Acad Sci U S A 101(23):8658-63
5)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41