MRE11/YMR224C Protein Information Help

Standard Name Mre11p
Systematic Name Ymr224cp
Alias Rad58p , Xrs4p , Ngs1p
ORF Classification Verified
Description Subunit of the MRX complex with Rad50p and Xrs2p; complex functions in repair of DNA double-strand breaks and in telomere stability; exhibits nuclease activity that appears to be required for MRX function; widely conserved; forms nuclear foci upon DNA replication stress (1, 2, 3, 4)
Name Description Meiotic REcombination 5
Experimental Data
Molecules/cell 432 6
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 692
Molecular Weight (Da) 77,650
Isoelectric Point (pI) 5.71

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Mre11p (InterPro)
Physical Interactions There are 84 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI000004C4DA | P32829
MIPS: YMR224C
NCBI: 1513065 | 1709096 | 2209265 | 6323880 | 887605 | NP_013951.1
GenBank/EMBL/DDBJ: DAA10123.1 | D11463 | U60829 | Z49939
Amino Acid Sequence (or in FASTA format)
 
       1  MDYPDPDTIR ILITTDNHVG YNENDPITGD DSWKTFHEVM MLAKNNNVDM
      51  VVQSGDLFHV NKPSKKSLYQ VLKTLRLCCM GDKPCELELL SDPSQVFHYD
     101  EFTNVNYEDP NFNISIPVFG ISGNHDDASG DSLLCPMDIL HATGLINHFG
     151  KVIESDKIKV VPLLFQKGST KLALYGLAAV RDERLFRTFK DGGVTFEVPT
     201  MREGEWFNLM CVHQNHTGHT NTAFLPEQFL PDFLDMVIWG HEHECIPNLV
     251  HNPIKNFDVL QPGSSVATSL CEAEAQPKYV FILDIKYGEA PKMTPIPLET
     301  IRTFKMKSIS LQDVPHLRPH DKDATSKYLI EQVEEMIRDA NEETKQKLAD
     351  DGEGDMVAEL PKPLIRLRVD YSAPSNTQSP IDYQVENPRR FSNRFVGRVA
     401  NGNNVVQFYK KRSPVTRSKK SGINGTSISD RDVEKLFSES GGELEVQTLV
     451  NDLLNKMQLS LLPEVGLNEA VKKFVDKDEK TALKEFISHE ISNEVGILST
     501  NEEFLRTDDA EEMKALIKQV KRANSVRPTP PKENDETNFA FNGNGLDSFR
     551  SSNREVRTGS PDITQSHVDN ESRITHISQA ESSKPTSKPK RVRTATKKKI
     601  PAFSDSTVIS DAENELGDNN DAQDDVDIDE NDIIMVSTDE EDASYGLLNG
     651  RKTKTKTRPA ASTKTASRRG KGRASRTPKT DILGSLLAKK RK*

external links for Mre11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
Aspergillus (AspGD) BioPIXIE MIPS YeastRC Public Image Repository
Candida (CGD) CYC2008 (complexes) Pfam domains
Candida (CandidaDB) Complexome YeastRC Structure Prediction (Seattle)
YGOB DIP

YOGY GeneMANIA

References cited on this page View Complete Literature Guide for Mre11p
1) D'Amours D and Jackson SP  (2002) The Mre11 complex: at the crossroads of dna repair and checkpoint signalling. Nat Rev Mol Cell Biol 3(5):317-27
2) Moncalian G, et al.  (2004) The rad50 signature motif: essential to ATP binding and biological function. J Mol Biol 335(4):937-51
3) Lewis LK, et al.  (2004) Role of the nuclease activity of Saccharomyces cerevisiae Mre11 in repair of DNA double-strand breaks in mitotic cells. Genetics 166(4):1701-13
4) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
5) Ajimura M, et al.  (1993) Identification of new genes required for meiotic recombination in Saccharomyces cerevisiae. Genetics 133(1):51-66
6) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41