TOM40/YMR203W Protein Information

Standard Name	Tom40p 1
Systematic Name	Ymr203wp
Alias	Isp42p 2 , Mom38p
ORF Classification	Verified
Description	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore (3, 4, 5, 6, 7)
Name Description	Translocase of the Outer Mitochondrial membrane 1

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	387
Molecular Weight (Da)	42,038
Isoelectric Point (pI)	5.27

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Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Tom40p (InterPro)
Physical Interactions	There are 82 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000053281 \| P23644 MIPS: YMR203W NCBI: 124912 \| 3838 \| 51013493 \| 6323859 \| 736300 \| NP_013930.1 GenBank/EMBL/DDBJ: DAA10102.1 \| AY693021 \| X56885 \| Z48755

Amino Acid Sequence (or in FASTA format)
1 MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS 51 HRQSLELVNP GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT 101 SHTFSIGSQA LPKYAFSALF ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI 151 SKVNLQISDG QPTMCQLEQD YQASDFSVNV KTLNPSFSEK GEFTGVAVAS 201 FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK QDWIFSGQLQ 251 ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS 301 TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND 351 TKIGCGLQFE TAGNQELLML QQGLDADGNP LQALPQL*

Amino Acid Sequence (or in FASTA format)

       1  MSAPTPLAEA SQIPTIPALS PLTAKQSKGN FFSSNPISSF VVDTYKQLHS
      51  HRQSLELVNP GTVENLNKEV SRDVFLSQYF FTGLRADLNK AFSMNPAFQT
     101  SHTFSIGSQA LPKYAFSALF ANDNLFAQGN IDNDLSVSGR LNYGWDKKNI
     151  SKVNLQISDG QPTMCQLEQD YQASDFSVNV KTLNPSFSEK GEFTGVAVAS
     201  FLQSVTPQLA LGLETLYSRT DGSAPGDAGV SYLTRYVSKK QDWIFSGQLQ
     251  ANGALIASLW RKVAQNVEAG IETTLQAGMV PITDPLMGTP IGIQPTVEGS
     301  TTIGAKYEYR QSVYRGTLDS NGKVACFLER KVLPTLSVLF CGEIDHFKND
     351  TKIGCGLQFE TAGNQELLML QQGLDADGNP LQALPQL*

external links for Tom40p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
Aspergillus (AspGD)	BioPIXIE	MIPS	YeastGFP
Candida (CGD)	CYC2008 (complexes)	Pfam domains
Candida (CandidaDB)	Complexome	YeastRC Structure Prediction (Seattle)
YGOB	DIP
YOGY	GeneMANIA
	YeastRC Mass Spec (Seattle)

References cited on this page View Complete Literature Guide for Tom40p

1)	Pfanner N, et al. (1996) Uniform nomenclature for the protein transport machinery of the mitochondrial membranes. Trends Biochem Sci 21(2):51-2
2)	Vestweber D, et al. (1989) A 42K outer-membrane protein is a component of the yeast mitochondrial protein import site. Nature 341(6239):205-9
3)	Meisinger C, et al. (1999) The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore. Cell Mol Life Sci 56(9-10):817-24
4)	Rapaport D and Neupert W (1999) Biogenesis of Tom40, core component of the TOM complex of mitochondria. J Cell Biol 146(2):321-31
5)	Ryan MT, et al. (2000) The transport machinery for the import of preproteins across the outer mitochondrial membrane. Int J Biochem Cell Biol 32(1):13-21
6)	Chacinska A, et al. (2003) Mitochondrial translocation contact sites: separation of dynamic and stabilizing elements in formation of a TOM-TIM-preprotein supercomplex. EMBO J 22(20):5370-81
7)	Pfanner N, et al. (2004) Assembling the mitochondrial outer membrane. Nat Struct Mol Biol 11(11):1044-8