CIK1/YMR198W Protein Information Help

Standard Name Cik1p 1
Systematic Name Ymr198wp
ORF Classification Verified
Description Kinesin-associated protein; required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; CIK1 has a paralog, VIK1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)
Name Description Chromosome Instability and Karyogamy 1
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 594
Molecular Weight (Da) 69,069
Isoelectric Point (pI) 6.36

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Cik1p (InterPro)
Physical Interactions There are 38 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00001279A0 | Q01649
MIPS: YMR198W
NCBI: 171222 | 399252 | 6323854 | 642291 | NP_013925.1
GenBank/EMBL/DDBJ: DAA10097.1 | M96439 | Z47815
Amino Acid Sequence (or in FASTA format)
 
       1  MNNSKIPKLS FHSDPNNVTR DFPKTKRQKV QKREMDMILT PNNNKLNILH
      51  SSGSGIRRCY TDDTSATYTK KLTFGGDPKI IERVKNNERK VRKDIDSLLN
     101  AISEIEKESV RIHARELPAI TLELDAKVKA CRELQNEIDG LSTEMDLKDN
     151  QCDLQRKNVE LSSKNIVSMH AVKVQEFEND LEEELSNAKR EWTYKLMEVE
     201  NLKPDERLTD EMRQLKTEFE EVNRKLFILQ NENENECKNY KKELDKKFEI
     251  FKKVKNDARI ELDGEQERLS KVLKDLQDTH GELKENIKTC RDEFNDFEKR
     301  IGEAEVNFHS MELAVVPLKK KLASTSQALT QVQEEKKQVE GEANNWKKKY
     351  VNELEKVQQE LYTRQNLATS IEEIKGYTRC FAYANERQMP DEFHINYVDR
     401  CICENSGEKR VQVFDRVVLE EIHKDHKRLY NECIPFLEKY ISKLINCSII
     451  VVSQQPTAPM KKTLLKQLIE QYGENYKMTL NILHLDGSIK HSDVGLDNPT
     501  EIRDLSQDEE CMNILTLDTK LGKDEESHSM NIYIGSMSTV QLNRELDDAP
     551  SVLSHILTKT KQCFVFKINA GENIEKALAL AGKLKRTITL PQLD*

external links for Cik1p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily YPL+
Ashbya (AGD) BOND GPMdb (Mass Spec.) YeastGFP
YGOB BioPIXIE MIPS YeastRC Public Image Repository
YOGY CYC2008 (complexes) Pfam domains

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Cik1p
1) Page BD and Snyder M  (1992) CIK1: a developmentally regulated spindle pole body-associated protein important for microtubule functions in Saccharomyces cerevisiae. Genes Dev 6(8):1414-29
2) Barrett JG, et al.  (2000) The Kar3p kinesin-related protein forms a novel heterodimeric structure with its associated protein Cik1p. Mol Biol Cell 11(7):2373-85
3) Page BD, et al.  (1994) Localization of the Kar3 kinesin heavy chain-related protein requires the Cik1 interacting protein. J Cell Biol 124(4):507-19
4) Manning BD and Snyder M  (2000) Drivers and passengers wanted! the role of kinesin-associated proteins. Trends Cell Biol 10(7):281-9
5) Cottingham FR, et al.  (1999) Novel roles for saccharomyces cerevisiae mitotic spindle motors. J Cell Biol 147(2):335-50
6) Shanks RM, et al.  (2001) The Kar3-interacting protein Cik1p plays a critical role in passage through meiosis I in Saccharomyces cerevisiae. Genetics 159(3):939-51
7) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61