RGM1/YMR182C Protein Information

Standard Name	Rgm1p 1
Systematic Name	Ymr182cp
ORF Classification	Verified
Description	Putative zinc finger DNA binding transcription factor; contains two N-terminal C2H2 zinc fingers and C-terminal proline rich domain; overproduction impairs cell growth and induces expression of genes involved in monosaccharide catabolism and aldehyde metabolism; regulates expression of of Y-prime telomeric elements and subtelomeric COS genes; RGM1 has a paralog, USV1, that arose from the whole genome duplication (1, 2, 3, 4, 5, 6, 7)

Experimental Data
Molecules/cell	1230 8

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	211
Molecular Weight (Da)	23,855
Isoelectric Point (pI)	10.4

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Rgm1p (InterPro)
Physical Interactions	There are 9 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI0000133817 \| Q00453 MIPS: YMR182C NCBI: 1710120 \| 4318 \| 6323836 \| 854452 \| NP_013907.1 GenBank/EMBL/DDBJ: DAA10079.1 \| X59861 \| Z49808

Amino Acid Sequence (or in FASTA format)
1 MRGKQPKRNK DNASVKRNYR CVGYPDCNMS FNRTEHLARH IRKHTGEKPF 51 QCNICLKFFS RIDNLRQHQS SVHSDVDLMS LRRLQQSANS TANDPNATRM 101 FPQLRPYGIV VQPAPVPYNL PISTPASPQD TISLYAPPYF PHPMPSAPIP 151 LPHQPPPLPI YSYMQPLFLN HTPIQNHNIV ELPPDSSDTP ASPSKVQSFD 201 QAKDASPNAK K*

Amino Acid Sequence (or in FASTA format)

       1  MRGKQPKRNK DNASVKRNYR CVGYPDCNMS FNRTEHLARH IRKHTGEKPF
      51  QCNICLKFFS RIDNLRQHQS SVHSDVDLMS LRRLQQSANS TANDPNATRM
     101  FPQLRPYGIV VQPAPVPYNL PISTPASPQD TISLYAPPYF PHPMPSAPIP
     151  LPHQPPPLPI YSYMQPLFLN HTPIQNHNIV ELPPDSSDTP ASPSKVQSFD
     201  QAKDASPNAK K*

external links for Rgm1p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	DIP
	GeneMANIA

References cited on this page View Complete Literature Guide for Rgm1p

1)	Estruch F (1991) The yeast putative transcriptional repressor RGM1 is a proline-rich zinc finger protein. Nucleic Acids Res 19(18):4873-7
2)	Bohm S, et al. (1997) Variations of the C2H2 zinc finger motif in the yeast genome and classification of yeast zinc finger proteins. Nucleic Acids Res 25(12):2464-9
3)	Byrne KP and Wolfe KH (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
4)	Chua G, et al. (2006) Identifying transcription factor functions and targets by phenotypic activation. Proc Natl Acad Sci U S A 103(32):12045-50
5)	Mak HC, et al. (2009) Dynamic reprogramming of transcription factors to and from the subtelomere. Genome Res 19(6):1014-25
6)	Smith JJ, et al. (2011) Environment-responsive transcription factors bind subtelomeric elements and regulate gene silencing. Mol Syst Biol 7():455
7)	Joshi A, et al. (2011) Structural and functional organization of RNA regulons in the post-transcriptional regulatory network of yeast. Nucleic Acids Res 39(21):9108-17
8)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41