ALD2/YMR170C Protein Information

Standard Name	Ald2p
Systematic Name	Ymr170cp
ORF Classification	Verified
Description	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p (1, 2)
Name Description	ALdehyde Dehydrogenase

Experimental Data
Molecules/cell	2070 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	506
Molecular Weight (Da)	55,187
Isoelectric Point (pI)	5.32

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ald2p (InterPro)
Physical Interactions	There are 4 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012925D \| P47771 MIPS: YMR170C NCBI: 1706382 \| 6323822 \| 758648 \| 825575 \| NP_013893.1 GenBank/EMBL/DDBJ: DAA10066.1 \| X85987 \| Z49705
External Classifications	EC: 1.2.1.3 [Aldehyde dehydrogenase (NAD(+))]

Amino Acid Sequence (or in FASTA format)
1 MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT 51 SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT 101 LAALETLDAG KPYHSNAKGD LAQILQLTRY FAGSADKFDK GATIPLTFNK 151 FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ GALAAGNTVI IKPAENTSLS 201 LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK ISFTGSTKVG 251 GFVLEASGQS NLKDVTLECG GKSPALVFED ADLDKAIDWI AAGIFYNSGQ 301 NCTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS 351 STQYDRIKSY IERGKREEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPQTS 401 KLLQDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA 451 RDIKAGTVWI NSSNDEDVTV PFGGFKMSGI GRELGQSGVD TYLQTKAVHI 501 NLSLDN*

Amino Acid Sequence (or in FASTA format)

       1  MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
      51  SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
     101  LAALETLDAG KPYHSNAKGD LAQILQLTRY FAGSADKFDK GATIPLTFNK
     151  FAYTLKVPFG VVAQIVPWNY PLAMACWKLQ GALAAGNTVI IKPAENTSLS
     201  LLYFATLIKK AGFPPGVVNI VPGYGSLVGQ ALASHMDIDK ISFTGSTKVG
     251  GFVLEASGQS NLKDVTLECG GKSPALVFED ADLDKAIDWI AAGIFYNSGQ
     301  NCTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
     351  STQYDRIKSY IERGKREEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPQTS
     401  KLLQDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
     451  RDIKAGTVWI NSSNDEDVTV PFGGFKMSGI GRELGQSGVD TYLQTKAVHI
     501  NLSLDN*

external links for Ald2p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	Organelle DB
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YPL+
YGOB	BioPIXIE	MIPS	YeastGFP
YOGY	CYC2008 (complexes)	Pfam domains	YeastRC Public Image Repository
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Ald2p

1)	Navarro-Avino JP, et al. (1999) A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes. Yeast 15(10A):829-42
2)	White WH, et al. (2003) Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae. Genetics 163(1):69-77
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41