ALD3/YMR169C Protein Information

Standard Name	Ald3p
Systematic Name	Ymr169cp
ORF Classification	Verified
Description	Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose (1, 2)
Name Description	ALdehyde Dehydrogenase

Experimental Data
Molecules/cell	172 3

Predicted Sequence	Formatted Sequence or sequence in FASTA format
Length (a.a.)	506
Molecular Weight (Da)	55,385
Isoelectric Point (pI)	5.51

Click on image for expanded interactive view

Post-translational Modifications	PhosphoGRID \| PhosphoPep Database
Domains/motifs	See the graphical view and list of proteins that share domains/motifs in common with Ald3p (InterPro)
Physical Interactions	There are 2 total physical interactions (BioGRID)
Homologs	PDB Homologs \| BLASTP \| BLASTP v. fungi \| Fungal Alignment \| Synteny Viewer
External Sequence Databases	EBI: UPI000012925E \| P54114 MIPS: YMR169C NCBI: 1706380 \| 6323821 \| 825574 \| NP_013892.1 GenBank/EMBL/DDBJ: DAA10065.1 \| Z49705
External Classifications	EC: 1.2.1.3 [Aldehyde dehydrogenase (NAD(+))] EC: 1.2.1.5 [Aldehyde dehydrogenase (NAD(P)(+))]

Amino Acid Sequence (or in FASTA format)
1 MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT 51 SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT 101 LAALETLDAG KPFHSNAKQD LAQIIELTRY YAGAVDKFNM GETIPLTFNK 151 FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ GALAAGNTVI IKPAENTSLS 201 LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK ISFTGSTKVG 251 GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ 301 ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS 351 STQYDRIKSY IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS 401 KLLRDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA 451 RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI GRESGDTGVD NYLQIKSVHV 501 DLSLDK*

Amino Acid Sequence (or in FASTA format)

       1  MPTLYTDIEI PQLKISLKQP LGLFINNEFC PSSDGKTIET VNPATGEPIT
      51  SFQAANEKDV DKAVKAARAA FDNVWSKTSS EQRGIYLSNL LKLIEEEQDT
     101  LAALETLDAG KPFHSNAKQD LAQIIELTRY YAGAVDKFNM GETIPLTFNK
     151  FAYTLKVPFG VVAQIVPWNY PLAMACRKMQ GALAAGNTVI IKPAENTSLS
     201  LLYFATLIKK AGFPPGVVNV IPGYGSVVGK ALGTHMDIDK ISFTGSTKVG
     251  GSVLEASGQS NLKDITLECG GKSPALVFED ADLDKAIEWV ANGIFFNSGQ
     301  ICTANSRVYV QSSIYDKFVE KFKETAKKEW DVAGKFDPFD EKCIVGPVIS
     351  STQYDRIKSY IERGKKEEKL DMFQTSEFPI GGAKGYFIPP TIFTDVPETS
     401  KLLRDEIFGP VVVVSKFTNY DDALKLANDT CYGLASAVFT KDVKKAHMFA
     451  RDIKAGTVWI NQTNQEEAKV PFGGFKMSGI GRESGDTGVD NYLQIKSVHV
     501  DLSLDK*

external links for Ald3p

Homologs	Interaction Resources	Protein databases/Other	Localization Resources
BLASTP (NCBI)	BioGRID	SCOP Superfamily	YPL+
Ashbya (AGD)	BOND	GPMdb (Mass Spec.)	YeastGFP
YGOB	BioPIXIE	MIPS	YeastRC Public Image Repository
YOGY	CYC2008 (complexes)	Pfam domains
	Complexome	YeastRC Structure Prediction (Seattle)
	GeneMANIA

References cited on this page View Complete Literature Guide for Ald3p

1)	Navarro-Avino JP, et al. (1999) A proposal for nomenclature of aldehyde dehydrogenases in Saccharomyces cerevisiae and characterization of the stress-inducible ALD2 and ALD3 genes. Yeast 15(10A):829-42
2)	White WH, et al. (2003) Specialization of function among aldehyde dehydrogenases: the ALD2 and ALD3 genes are required for beta-alanine biosynthesis in Saccharomyces cerevisiae. Genetics 163(1):69-77
3)	Ghaemmaghami S, et al. (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41