RIM11/YMR139W Protein Information Help

Standard Name Rim11p 1, 2
Systematic Name Ymr139wp
Alias Gsk3p , Mds1p
ORF Classification Verified
Description Protein kinase; required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta; protein abundance increases in response to DNA replication stress; RIM11 has a paralog, MRK1, that arose from the whole genome duplication (3, 4, 5, 6, 7)
Name Description Regulator of IME2 1
Experimental Data
Molecules/cell 6990 8
Predicted Sequence Formatted Sequence or sequence in FASTA format
Length (a.a.) 370
Molecular Weight (Da) 43,004
Isoelectric Point (pI) 6.51

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Post-translational Modifications PhosphoGRID | PhosphoPep Database
Domains/motifs See the graphical view and list of proteins that share domains/motifs in common with Rim11p (InterPro)
Physical Interactions There are 91 total physical interactions (BioGRID)
Homologs PDB Homologs | BLASTP | BLASTP v. fungi | Fungal Alignment | Synteny Viewer
External Sequence Databases EBI: UPI00000532AA | P38615
MIPS: YMR139W
NCBI: 295639 | 450781 | 45269878 | 535777 | 585472 | 606437 | 6323788 | NP_013859.1 | NM_001182641.1
GenBank/EMBL/DDBJ: DAA10036.1 | AY557994 | L12761 | L29284 | U03280 | Z47071
External Classifications EC: 2.7.11.1 [Non-specific serine/threonine protein kinase]
Amino Acid Sequence (or in FASTA format)
 
       1  MNIQSNNSPN LSNNIVSKQV YYAHPPPTID PNDPVQISFP TTEVVGHGSF
      51  GVVFATVIQE TNEKVAIKKV LQDKRFKNRE LEIMKMLSHI NIIDLKYFFY
     101  ERDSQDEIYL NLILEYMPQS LYQRLRHFVH QRTPMSRLEI KYYMFQLFKS
     151  LNYLHHFANV CHRDIKPQNL LVDPETWSLK LCDFGSAKQL KPTEPNVSYI
     201  CSRYYRAPEL IFGATNYTNQ IDIWSSGCVM AELLLGQPMF PGESGIDQLV
     251  EIIKILGTPS KQEICSMNPN YMEHKFPQIK PIPLSRVFKK EDDQTVEFLA
     301  DVLKYDPLER FNALQCLCSP YFDELKLDDG KINQITTDLK LLEFDENVEL
     351  GHLSPDELSS VKKKLYPKSK *

external links for Rim11p
Homologs Interaction Resources Protein databases/Other Localization Resources
BLASTP (NCBI) BioGRID SCOP Superfamily Organelle DB
Ashbya (AGD) BOND GPMdb (Mass Spec.) YPL+
YGOB BioPIXIE MIPS YeastGFP
YOGY CYC2008 (complexes) Pfam domains YeastRC Public Image Repository

Complexome YeastRC Structure Prediction (Seattle)

DIP


GeneMANIA

References cited on this page View Complete Literature Guide for Rim11p
1) Mitchell AP and Bowdish KS  (1992) Selection for early meiotic mutants in yeast. Genetics 131(1):65-72
2) Su SS and Mitchell AP  (1993) Identification of functionally related genes that stimulate early meiotic gene expression in yeast. Genetics 133(1):67-77
3) Malathi K, et al.  (1997) Interaction of yeast repressor-activator protein Ume6p with glycogen synthase kinase 3 homolog Rim11p. Mol Cell Biol 17(12):7230-6
4) Puziss JW, et al.  (1994) MDS1, a dosage suppressor of an mck1 mutant, encodes a putative yeast homolog of glycogen synthase kinase 3. Mol Cell Biol 14(1):831-9
5) Rubin-Bejerano I, et al.  (2004) The in vivo activity of Ime1, the key transcriptional activator of meiosis-specific genes in Saccharomyces cerevisiae, is inhibited by the cyclic AMP/protein kinase A signal pathway through the glycogen synthase kinase 3-beta homolog Rim11. Mol Cell Biol 24(16):6967-79
6) Byrne KP and Wolfe KH  (2005) The Yeast Gene Order Browser: combining curated homology and syntenic context reveals gene fate in polyploid species. Genome Res 15(10):1456-61
7) Tkach JM, et al.  (2012) Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress. Nat Cell Biol 14(9):966-76
8) Ghaemmaghami S, et al.  (2003) Global analysis of protein expression in yeast. Nature 425(6959):737-41